Activation of Nrf-2 by tBHQ enhances proliferation of HRGECs. A, dose response for incubation with tBHQ over 24hr. B, effect of si-RNA to Nrf-2, compared to scrambled si-RNA. Si-SCR, scrambled si-RNA; Si-Nrf-2, Nrf-2-siRNA; open boxes, vehicle, solid boxes; tBHQ (20 µmol∙l−1 in Panel B for 24 hr). Mean± SEM values (n=6 per group). Compared to vehicle; ***P < 0.005. Compared to si-SCR: ††, P<0.01; †††, P<0.005