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. 2015 Mar 13;11(3):e1004050. doi: 10.1371/journal.pcbi.1004050

Fig 4. Experimental validation of in silico predicted treatments using ivdTEM.

Fig 4

TEM differentiated in vitro were exposed to the treatments predicted in silico and their changes in TIE-2 and VEGFR-1 expression (A) and pro-angiogenic activity (B) measured by flow cytometry and in vitro angiogenesis sprouting assay respectively. The impact of inhibitory treatments was examined on ivdTEM previously treated with TNF-α/PlGF/ANG-2 (panels A and B). Significant variations (P < 0.05) are indicated with an asterisk. In panel A, small and large asterisks referred to VEGFR-1 and TIE-2 expression respectively.