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. 2015 Mar 13;11(3):e1004050. doi: 10.1371/journal.pcbi.1004050

Fig 7. Tie-2 and VEGFR-1, and Ang-2 and PIGF represent attractive targets in breast cancer (A) Correlation of Ang-2 and PlGF and CD14 protein expression levels in the tumor with tumor size in 17 patients.

Fig 7

The significance of their linear correlation is shown by Pearson r and p values. (B-F) Survival analysis. The good prognostic effect of the lower expression of CD14, ANG-2 and PIGF (B) is reflected by the clear separation from the over expression group on the Kaplan-Meier plot, with a P value of 0.0257 from a Log-rank test (F), whereas only ANG-2 (C) or PIGF (D) combined with CD14 separate worse lower and over expression groups, suggesting a synergistic effect of ANG-2 and PIGF to promote CD14-mediated angiogenesis and the corresponding impact on patient relapse free survival. (E) Shows the survival curve of lower expression patients for the three cases.