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. 2015 Mar 13;10(3):e0120808. doi: 10.1371/journal.pone.0120808

Fig 4. Effects of D1 related drugs on the INa.

Fig 4

A) Recordings of the INa in control condition and after perfusion of A-68930 (300 nM). B) Current-voltage relationship of the INa under control conditions and after 300 nM A-68930. The maximum decrease of the current was 29 ± 4% at −10 mV. C) Steady state inactivation of the INa in control conditions and after 300 nM A-68930, which caused a leftward shift of the inactivation. D). Bar graph comparing the inhibitory effect of 100 nM dihidrexidine with A-68930 effect. Non-significant difference was found (P = 0.445; unpaired t-test). E) Current-voltage relationship of the INa in control conditions (with 100 μM SCH-23390), and after the co-application of 300 nM A-68930. F) Steady state inactivation of the INa in control (with 100 μM SCH-23390) and after A-68930 + SCH-23390, which caused non-significant changes. G) Typical recordings of the INa showing that SCH-23390 significantly reduced the inhibitory action of 300 nM A-68930.