Table 1. Action potential parameters in control conditions and after drug use.
Drug | Parameter | Control | Effect | P-value | Tendency |
---|---|---|---|---|---|
A-68930 (300 nM) n = 4 | Threshold (mV) | -25 ± 1.5 | -24 ± 3.32 | 0.76 | ↓ |
Amplitude (mV) | 132 ± 7 | 137 ± 11 | 0.3 | ↑ | |
MDR (mV/ms) | 140 ± 23 | 137 ± 24 | 0.82 | ↓ | |
MRR (mV/ms) | -124 ± 15 | -111 ± 19 | 0.12 | ↓ | |
Latency (s) | 0.9 ± 0.04 | 1 ± 0.03 | 0.22 | ↑ | |
Duration (s) | 2 ± 0.3 | 2.2 ± 0.4 | 0.18 | ↑ | |
Quinpirole (1 μM) n = 4 | Threshold (mV) | -40 ± 6 | -46 ± 4 | 0.4 | ↑ |
Amplitude (mV) | 88 ± 7 | 88 ± 6 | 0.83 | ↓ | |
MDR (mV/ms) | 144 ± 43 | 131 ± 33 | 0.42 | ↓ | |
MRR (mV/ms) | -154 ± 33 | -144 ± 23 | 0.4 | ↓ | |
Latency (s) | 0.5 ± 0.2 | 0.4 ± 0.1 | 0.15 | ↓ | |
Duration (s) | 1.6 ± 0.3 | 1.7 ± 0.3 | 0.06 | ↑ | |
A-68930 (300 nM) + quinpirole (1 μ) n = 6 | Threshold (mV) | -42 ± 4 | -42 ± 4 | 0.94 | ↓ |
Amplitude (mV) | 129 ± 7 | 125 ± 8 | 0.22 | ↓ | |
MDR (mV/ms) | 146 ± 24 | 130 ± 23 | 0.28 | ↓ | |
MRR (mV/ms) | -157 ± 22 | -149 ± 19 | 0.45 | ↓ | |
Latency (s) | 1.2 ± 0.1 | 1.2 ± 0.1 | 0.57 | ↑ | |
Duration (s) | 1.8 ± 0.2 | 1.8 ± 0.2 | 0.39 | ↑ | |
Dihydrexidine (100 nM) n = 10 | Threshold (mV) | -41 ± 2 | -40 ± 1.6 | 0.52 | ↓ |
Amplitude (mV) | 116 ± 6 | 114 ± 9 | 0.16 | ↓ | |
MDR (mV/ms) | 144 ± 17 | 272 ± 147 | 0.4 | ↑ | |
MRR (mV/ms) | -154 ± 13 | -140 ± 14 | * 0.005 | ↓ | |
Latency (s) | 1.7 ± 0.1 | 1.7 ± 0.1 | 0.25 | ↑ | |
Duration (s) | 0.5 ± 0.1 | 0.5 ± 0.1 | * 0.005 | ↑ |