Skip to main content
. 2015 Mar 13;10(3):e0120808. doi: 10.1371/journal.pone.0120808

Table 1. Action potential parameters in control conditions and after drug use.

Drug Parameter Control Effect P-value Tendency
A-68930 (300 nM) n = 4 Threshold (mV) -25 ± 1.5 -24 ± 3.32 0.76
Amplitude (mV) 132 ± 7 137 ± 11 0.3
MDR (mV/ms) 140 ± 23 137 ± 24 0.82
MRR (mV/ms) -124 ± 15 -111 ± 19 0.12
Latency (s) 0.9 ± 0.04 1 ± 0.03 0.22
Duration (s) 2 ± 0.3 2.2 ± 0.4 0.18
Quinpirole (1 μM) n = 4 Threshold (mV) -40 ± 6 -46 ± 4 0.4
Amplitude (mV) 88 ± 7 88 ± 6 0.83
MDR (mV/ms) 144 ± 43 131 ± 33 0.42
MRR (mV/ms) -154 ± 33 -144 ± 23 0.4
Latency (s) 0.5 ± 0.2 0.4 ± 0.1 0.15
Duration (s) 1.6 ± 0.3 1.7 ± 0.3 0.06
A-68930 (300 nM) + quinpirole (1 μ) n = 6 Threshold (mV) -42 ± 4 -42 ± 4 0.94
Amplitude (mV) 129 ± 7 125 ± 8 0.22
MDR (mV/ms) 146 ± 24 130 ± 23 0.28
MRR (mV/ms) -157 ± 22 -149 ± 19 0.45
Latency (s) 1.2 ± 0.1 1.2 ± 0.1 0.57
Duration (s) 1.8 ± 0.2 1.8 ± 0.2 0.39
Dihydrexidine (100 nM) n = 10 Threshold (mV) -41 ± 2 -40 ± 1.6 0.52
Amplitude (mV) 116 ± 6 114 ± 9 0.16
MDR (mV/ms) 144 ± 17 272 ± 147 0.4
MRR (mV/ms) -154 ± 13 -140 ± 14 * 0.005
Latency (s) 1.7 ± 0.1 1.7 ± 0.1 0.25
Duration (s) 0.5 ± 0.1 0.5 ± 0.1 * 0.005