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. 2014 Dec 11;6(2):1020–1030. doi: 10.18632/oncotarget.2741

Figure 2. Flow cytometric analysis of the cell cycle phase distribution.

Figure 2

(A) DNA content of MDA-MB-231-NC and MDA-MB-231-shCXCR4 cells treated with cisplatin (0, 1 μM) was analyzed by propidium iodide (PI) staining. (B) DNA content of MDA-MB-468-NC and MDA-MB-468-CXCR4 cells treated with cisplatin (0, 1 μM) was analyzed by propidium iodide (PI) staining. (C) The effect of CXCR4 knockdown on cell cycle in MDA-MB-231 cells. From the left to right, the phases of the cell cycle were G1-phase, S-phase, and G2/M-phase. (D) The effect of CXCR4 overexpression on cell cycle in MDA-MB-468 cells. From the left to right, the phases of the cell cycle were G1-phase, S-phase, and G2/M-phase. (E) After treatment with 0 and 1 μM cisplatin for 48 h, the fraction of apoptotic cells was analyzed by flow cytometry. *p < 0.05, **p < 0.01, as compared with untreated cells.