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. 2014 Dec 11;6(2):1020–1030. doi: 10.18632/oncotarget.2741

Figure 3. CXCR4 knockdown sensitizes TNBC to cisplatin in vivo.

Figure 3

(A) Gross appearance. Gross appearance and the primary tumors of each group are shown. (B) Growth curves of tumors for MDA-MB-231-NC and MDA-MB-231-shCXCR4 with cisplatin or 0.9% saline. (C) Immunohistochemical staining of xenograft tumors for PCNA (magnification = 40×). (D) Representative pictures of TUNEL-positive staining (brown) for MDA-MB-231-NC and MDA-MB-231-shCXCR4 xenografts. Apoptosis index was calculated as the number of apoptotic cells divided by the total number of tumor cells. *p < 0.05, **p < 0.01, as compared with untreated cells.