Figure 7. CD44 is a poor prognosis marker of localized PCa.

(a) CD44 expression in low-, medium-, and high-risk of human PCa was analyzed in IHC staining. (b &c) The expression levels of CD44 in 118 PCa patient samples were analyzed. A cut-off value of 10% was determined from the receiver operating characteristic (ROC) curve. Low and high CD44 staining were related to the disease risk but not age. (d & e) Kaplan-Meier curve analyzed the relationship between expression level of CD44 and biochemical recurrence or distant metastasis. Significance was defined as p<0.05(*) (f) Summarize the mechanism of ADT enhanced prostate cancer metastasis via alternation the TGFβ₁-CD44 signaling.