Table 2. Statistical evaluation of comparative gene expression.
The 3350 transcripts with the most significant changes in cell lines (p < 0.05) were compared to all transcripts (p < 0.05) in the five cancer data sets. Kappa analysis measured the significance of directionality. The number of up and down (↑,↓) regulated genes with the same direction of regulation in each cell lines compared to primary tissues are shown.
| Concordant expression with 812 primary breast tumors | MCFHER2 | BT474 | MDA453 |
|---|---|---|---|
| Genes with the same direction of regulation | 122↑, 151↓ | 196↑, 139↓ | 202↑, 147↓ |
| Number of genes with the opposite direction of regulation | 186 | 167 | 152 |
| Kappa Statistics | 0.201 | 0.329 | 0.391 |
| Standard Error | 0.045 | 0.044 | 0.044 |
| Z score | 4.466 | 7.451 | 8.929 |
| P value | 3.98E-06 | 4.61E-14 | 2.16E-19 |