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. 2014 Dec 1;6(2):1302–1314. doi: 10.18632/oncotarget.2744

Figure 1.

Figure 1

(A) A total of 5000 cells per well were incubated with AMACR-Cy5 and Scramble-Cy5 SmartFlare and tracked for 28 h by time-lapse microscopy (upper panel: Cy5, lower panel: bright field, 28 h); bar = 100μm; (B) Cy5 fluorescence intensity is significantly higher at 24 h in LNCAP cells compared to RWPE-1 cells (p < 0.0005, 8 replicates) and Scramble in both cell lines (p < 0.0005); (C–D) Selected tumor markers are significantly expressed in tumor cells (LNCAP) compared to benign cells (RWPE-1 and PNT2), p-values are indicated by stars: * = p < 0.05, **** = p < 0.00005) (E) typical heterogeneous cellular histology of prostate cancer tissue (immunohistological staining with AMACR and p63): 1 = benign gland, 2 = tumor gland, 3 = mesenchymal cells, arrows = p63 positive basal cells, dotted arrow = AMACR positive luminal cells (magnification 20x; bar = 100μm).