Figure 1. ERα expression increases in prostate cancer.

Representative images of ERα staining in human and mouse prostate cancer. Specimens of (A) Gleason score 6 and (B) Gleason score 9 human prostate cancer. (C) Benign lateral prostate tissue of a 5 month old control mouse (FVB) compared to (D) prostate cancer in an age-matched Hi-MYC mouse (ARR2/Pbsn-Myc). (E) Benign anterior prostate tissue from a 80-100 day old control mouse (PBiCre^+/−) compared to (F) malignant tissue in an age-matched PTEN-deficient animal (PBiCre^+/−;Pten^fl/fl). Scale bars equal 50 μm.