Table 1. Down-regulated gene categories in shERα cells related to small molecule metabolism.

p.val	q.val	Cellular functions
7.95E-06	0.010	cellular amino acid metabolic process
1.22E-05	0.011	mitochondrial inner membrane
2.29E-05	0.015	small molecule biosynthetic process
5.37E-05	0.029	carbon-carbon lyase activity
0.000324	0.081	sterol biosynthetic process
0.000351	0.081	deoxyribonucleotide catabolic process
0.000423	0.095	glycosaminoglycan biosynthetic process
0.000462	0.099	chondroitin sulfate biosynthetic process
0.000477	0.099	glycosaminoglycan metabolic process
0.000546	0.110	coenzyme metabolic process
0.000588	0.114	deoxyribose phosphate catabolic process
0.000653	0.116	single-organism carbohydrate catabolic process
0.000690	0.116	cofactor metabolic process
0.000691	0.116	hexose catabolic process
0.000778	0.120	NADP metabolic process
0.000787	0.120	proteoglycan biosynthetic process
0.000872	0.125	monosaccharide catabolic process
0.000978	0.128	generation of precursor metabolites and energy
0.001112	0.134	carbohydrate catabolic process