Table 3. Multivariate Cox model analyses of prognostic factors of LC.
| Variable | Hazard Ratio | 95%CI | p value |
|---|---|---|---|
| Years of diagnosis | P < 0.001 | ||
| 1988–1993 | 1 | ||
| 1994–1999 | 1.063 | 0.958–1.181 | |
| 2000–2003 | 0.900 | 0.816–0.992 | |
| Sex | P < 0.001 | ||
| Male | 1 | ||
| Female | 0.887 | 0.830–0.948 | |
| Age | P < 0.001 | ||
| ≤ 45 | 1 | ||
| > 45 | 1.286 | 1.158–1.427 | |
| Race | P < 0.001 | ||
| Caucasian | 1 | ||
| African American | 1.150 | 1.040–1.270 | |
| Others* | 0.859 | 0.801–0.922 | |
| Primary site | 0.584 | ||
| Liver | 1 | ||
| Intrahepatic bile duct | 1.053 | 0.875–1.269 | |
| Pathological grading | P < 0.001 | ||
| High/Moderate | 1 | ||
| Poor/undifferentiation | 1.431 | 1.342–1.526 | |
| Histological Type | 0.387 | ||
| Hepatocellular carcinoma | 1 | ||
| Cholangiocarcinoma | 0.907 | 0.772–1.065 | |
| Combined | 1.094 | 0.827–1.448 | |
| Stage | P < 0.001 | ||
| Localized | 1 | ||
| Regional | 1.540 | 1.444–1.643 | |
| Distant | 2.562 | 2.348–2.796 | |
| Tumor size | P < 0.001 | ||
| < 3cm | 1 | ||
| 3–5cm | 1.524 | 1.387–1.673 | |
| > 5cm | 1.932 | 1.768–2.110 |
*
including other (American Indian/AK Native, Asian/Pacific Islander) and unknowns.