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. 2015 Jan 6;6(2):679–695. doi: 10.18632/oncotarget.2707

Figure 3. Microscopic analysis of pathology in 12 week old gp130757FF xIL-1RT1−/− mice and in WT and IL-1RT1−/− mice administered with IL-11 for 7 days.

Figure 3

(A) H&E landscape of a wildtype proximal stomach (Fundus/Cardia) (i), normal cardia H&E (ii), and AB-PAS (iii). A developing lesion in the gp130757FF xIL-1RT1−/− cardia regions H&E (iv) and AB-PAS (v). (B) A pronounced lesion in the gp130757FF xIL-1RT1−/− stomach H&E (i) and AB-PAS (ii). (C) Glandular structure gp130757FF xIL-1RT1−/− stomach (H&E; i&ii, AB-PAS; iii–vi) and associated submucosal infiltrate (H&E; viii&ix). (D) Characteristic cardia in WT mice treated with saline (i) or IL-11 (ii) and in IL-1RT1–/– mice treated with saline (iii) or IL-11 (iv). Arrows in images indicate cardiac glands.