Table 6. Various assays on FL-HCC compared to whole genome sequencing results.
| Location | Type of Change | Genes Affected | Study | FL-HCC Cohort |
|---|---|---|---|---|
| 1q | Amplification | Numerous | Wilkens 2000 [12] | No change |
| 7p (55, 086, 714–55, 324, 313) | Mutation Amplification |
EGFR | No change Patonai 2012 [27] Polysomy without gene CNV Buckley 2005 [28] |
No change No duplication events |
| 12p (25, 357, 723–25, 403, 870) | Mutation | KRAS | No change Patonai 2012 [27] No change Muramori 2011 [58] |
No change No change |
| 17p (7, 565, 097–7, 590, 863) | Mutation | TP53 | No change Honda 1998 [59] |
No change |
| Mitochondrial DNA | Amplification Mutation |
Mitochondrial genome | Decreased DNA Vivekanandan 2010 [16] No consistent mutation Vivekanandan 2010 [16] |
No deletion events CPS1 mutated in 2 of 10 |
CNV = Copy number variation, FL-HCC = Fibrolamellar hepatocellular carcinoma