Fig. 2.

Changes in plasma KYNA concentration [median (quartile 1 and 3)] in patients who were anaesthetised intravenously and did not receive volatile anaesthetic (sevoflurane) prior to cardiopulmonary bypass (CPB) (NonSEV group) and patients who were anaesthetised intravenously and received sevoflurane (SEV group). Time points: 1 before anaesthesia and surgery (baseline); 2 just after surgery; 3 on the morning of postoperative day 1; 4 on the morning of postoperative day 2; and 5 on the morning of postoperative day 3. *p < 0.05, **p < 0.01 compared with baseline in the NonSEV group (Wilcoxon test). ^‡ p < 0.05, ^‡‡ p < 0.01, NonSEV group vs. SEV group