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. 2015 Feb 27;12:40. doi: 10.1186/s12974-015-0254-3

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© Sheean et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Effect of thymic stimulation by castration on M1 and M2 microglial activation in spinal cords of male SOD1 ^G93A mice. Immunohistochemical analysis of lumbar spinal cords of sham and castrated (Cx) SOD1^G93A mice at 120 days for (A) iNOS and (B) Arg1. M1 microglial activation shown by iNOS in sham SOD1^G93A mice is reduced by castration. M2 microglial activation shown by Arg1 in sham SOD1^G93A mice is increased by castration. Microglia were identified by Iba1 (not shown). Scale bar = 20 μm. Representative photomicrographs from two mice per group are shown.