Table 2.
Differentially regulated genes (DEGs) significantly associated with different behavioral responses, neuronal signaling processes and comorbid conditions
| q -Value | Associated DEGs | |
|---|---|---|
| Behavioral response | ||
| anxiety | 4.37E-17 | APP,BDNF,CCK,CNR1,CREB1,CRH,CRHR1,DRD2, FKBP5,FOS,MAPK1,NPY,NTRK2 |
| anxiety-like behavior | 3.10E-10 | APP,BDNF,CCK,CRH,CRHR1,MAPK1 |
| cognition | 9.54E-24 | AKT1,APP,BDNF,CNR1,CREB1,CRH,CRHR1, DRD2,EP300,ERK1/2,FOS,GNAI1,HDAC3,KL,MAPK1,MAPK3,NGF,NPY,NR3C1,NTRK1,NTRK2,PI3K (complex),THRB |
| cognitive impairment | 2.94E-10 | APP,BDNF,CNR1,CRH,DRD2,LEP,NGF,NPY |
| conditioning | 4.06E-12 | APP,BDNF,CNR1,CREB1,CRHR1,DRD2,ERK1/2, GNAI1,HDAC2,MAPK1,NPY |
| depressive disorder | 7.59E-10 | APP,BDNF,CCKBR,CREB1,CRH,DRD2,FKBP5, NR3C1,NTRK1,THRB |
| emotional behavior | 3.83E-15 | APP,BDNF,CCK,CNR1,CREB1,CRH,CRHR1,DRD2, MAPK1,MAPK3,NGF,NPY,NTRK2 |
| learning | 1.25E-21 | AKT1,APP,BDNF,CNR1,CREB1,CRH,CRHR1,DRD2, EP300,ERK1/2,FOS,GNAI1,HDAC3,HOMER1,MAPK1,MAPK3,NGF,NPY,NR3C1,NTRK1,NTRK2, PI3K (complex),THRB |
| locomotion | 6.56E-11 | APP,BDNF,CCKBR,CNR1,CRH,CRHR1,DRD2,LEP, NGF,NR3C1,STAT3 |
| long-term memory | 1.37E-15 | APP,BDNF,CREB1,CRH,DRD2,ERK1/2,GNAI1, HDAC3,MAPK1,NTRK2 |
| memory | 5.63E-20 | AKT1,APP,BDNF,CNR1,CREB1,CRH,CRHR1,DRD2, EP300,ERK1/2,GNAI1,HDAC3, HOMER1,MAPK1,NGF,NPY,NR3C1,NTRK1,NTRK2, PI3K (complex) |
| Mood Disorders | 2.80E-10 | AKT1,APP,BDNF,CCKBR,CREB1,CRH,DRD2, FKBP5,NR3C1,NTRK1,PLCG1,THRB |
| neurological signs | 2.63E-11 | AKT1,APP,BDNF,CCKBR,CNR1,CREB1, CTNNB1, DRD2,FOS,LEP,NGF,NPY,NTRK2,PRL |
| neuromuscular disease | 1.45E-10 | AKT1,APP,BDNF,CCKBR,CNR1,CREB1, CTNNB1,DRD2,FOS,LEP,NGF,NPY,NR3C1,NTRK2, PRL |
| object recognition memory | 1.69E-09 | APP,CNR1,EP300,HDAC3,NGF |
| post-traumatic stress disorder | 5.32E-14 | ADRA1A,ADRA1B,ADRA2A,ADRA2B,ADRA2C, ADRB1,CNR1,CNR2,DRD1,DRD2,DRD3,DRD4,DRD5,HTR1A,NR3C1,SLC6A4 |
| recognition memory | 2.36E-13 | APP,CNR1,EP300,GNAI1,HDAC3,MAPK1,NGF, NR3C1 |
| spatial learning | 3.72E-10 | APP,BDNF,CREB1,CRHR1,DRD2,FOS,NGF,NTRK2 |
| spatial memory | 2.95E-11 | AKT1,APP,BDNF,CNR1,CREB1,DRD2,NGF,NPY, NR3C1,PI3K (complex) |
| Neuronal signaling and neurogenesis | ||
| activation of neurons | 1.22E-10 | APP,BDNF,CCK,CNR1,CRH,FOS,LEP,NGF,PI3K (complex) |
| atrophy of neurons | 4.63E-10 | APP,BDNF,NGF,NTRK1,NTRK2 |
| axonogenesis | 1.84E-11 | AKT1,APP,BDNF,CCK,CREB1,DRD2,FOS,NGF,NTRK1,NTRK2 |
| cell death of hippocampal neurons | 1.51E-09 | AKT1,APP,BDNF,CRHR1,DRD2,LEP,NGF, NTRK2 |
| concentration of corticosterone | 1.28E-13 | APP,CNR1,CRH,CRHR1,DRD2,LEP,NPY,NR3C1, NTRK2,STAT3 |
| concentration of cyclic AMP | 3.58E-09 | ADCY,APP,BDNF,CCK,CNR1,CRH,DRD2,LEP,NGF, PRL |
| degeneration of neurons | 2.07E-09 | AKT1,APP,BDNF,CNR1,CREB1,EP300,NGF,NTRK2, STAT3 |
| dendritic growth/branching | 6.77E-11 | AKT1,APP,BDNF,CNR1,CRH,CRHR1,DRD2,NGF, NTRK2 |
| depolarization of cells | 1.34E-10 | APP,BDNF,CCK,CRH,FOS,LEP,NPY |
| disorder of basal ganglia | 2.28E-10 | AKT1,APP,BDNF,CCKBR,CNR1,CREB1, CTNNB1,DRD2,FOS,LEP,NGF,NPY,NTRK2,PRL |
| excitation of neurons | 4.23E-12 | APP,BDNF,CCK,CRH,FOS,NGF,NPY,NTRK2 |
| length of dendrites | 1.78E-12 | APP,BDNF,CRH,CRHR1,NGF,NTRK2 |
| long-term potentiation | 4.96E-15 | APP,BDNF,CNR1,CREB1,CRHR1,DRD2,ERK1/2, GNAI1,HDAC2,MAPK1,MAPK3,NGF,NPY,NTRK2, PI3K (complex) |
| long-term potentiation of synapse | 1.44E-12 | APP,BDNF,CNR1,CREB1,DRD2,GNAI1,HDAC2, MAPK3,NTRK2 |
| loss of dorsal root ganglion cells | 4.01E-10 | BDNF,NGF,NTRK1,NTRK2 |
| mobilization of Ca2+ | 3.95E-10 | BDNF,CCK,DRD2,GNAI1,GNB2, inositol triphosphate,NGF,NPY,PI3K (complex), PLCG1,RXFP3,SRC |
| neuronal cell death | 1.68E-15 | AKT1,APP,BDNF,CNR1,CREB1,CRHR1,CTNNB1,DRD2,EP300,ERK1/2,FOS,HDAC3,LEP,MAPK1,NGF,NR3C1,NTRK1,NTRK2,PI3K (complex),SRC,STAT3 |
| neuroprotection | 4.24E-09 | AKT1,APP,BDNF,CNR1,CRH,CRHR1,LEP,NGF,PI3K (complex) |
| neurotransmission | 3.60E-17 | APP,BDNF,CCK,CCKBR,CNR1,CRH,CRHR1, CTNNB1,DRD2,ERK1/2,GNAI1,HDAC2,LEP,NGF, NPY,NR3C1,SRC |
| proliferation of neuronal cells | 2.13E-09 | BDNF,CNR1,CTNNB1,DRD2,ERK1/2,LEP,NGF, NTRK2,PI3K (complex),STAT3 |
| quantity of ACTH in blood | 4.32E-09 | CNR1,DRD2,NR3C1,NTRK2 |
| quantity of neurons | 4.71E-12 | APP,BDNF,CREB1,DRD2,ERK1/2,LEP,NGF,NPY, NTRK1,NTRK2,PRL,THRB |
| quantity of pituitary cells | 2.10E-11 | CRH,CTNNB1,DRD2,LEP,PRL,THRB |
| release of acetylcholine | 3.84E-09 | APP,BDNF,CNR1,CRH,DRD2,NGF |
| release of Ca2+ | 3.82E-09 | AKT1,APP,BDNF,CCK,DRD2, inositol triphosphate,LEP,NGF,PI3K (complex),PLCG1,SRC |
| release of catecholamine | 3.32E-14 | APP,BDNF,CNR1,CRHR1,DRD2,LEP,NGF,NPY, NTRK1,NTRK2,PRL,SRC |
| release of dopamine | 1.84E-11 | APP,BDNF,CNR1,CRHR1,DRD2,LEP,NGF,NTRK2, PRL |
| release of L-glutamic acid | 1.12E-11 | ADCY,APP,BDNF,CCK,CNR1,CRH,DRD2,LEP,NGF, NPY |
| secretion of catecholamine | 2.06E-12 | AKT1,APP,CNR1,CRH,CRHR1,DRD2,NPY,NTRK1 |
| secretion of corticosterone | 4.27E-12 | BDNF,CRH,CRHR1,DRD2,LEP,NPY |
| secretion of neurotransmitter | 3.44E-10 | CCK,CNR1,CRH,DRD2,NGF,NPY,NTRK1,NTRK2 |
| stimulation of neurons | 4.28E-13 | APP,BDNF,CCK,CRH,FOS,LEP,NGF,NPY,NTRK2 |
| synaptogenesis | 2.22E-10 | APP,BDNF,CREB1,CTNNB1,HDAC2,NGF,NTRK1, NTRK2 |
| synthesis of neurotransmitter | 7.69E-10 | AKT1,APP,BDNF,CRH,NGF,NTRK1 |
| synthesis of steroid | 3.71E-09 | APP,BDNF,CREB1,CRH,CRHR1,LEP,MAPK1,NR3C1,PI3K (complex),PRL,PROX1 |
| Comorbid conditions | ||
| chronic inflammation | 1.56E-11 | ACE,ADORA2B,ADORA3,AGER,AOC3,C3,CCL5,CCR5,CD24A,CD28,CD47,CNR1,COX2,EDNRA,FABP4,FCER1A,FCER1G,FCGR1,FCGR3,GIF,HSPD1,IDO1,IL1B,ITGA2,JAK2,LBP,LTA,MIF,PDE5A,PIK3CG,PLA2G4A,PRKCA,PTGER3,PTGS2,STAT5A,STAT5B,TAC1,TGM2,TLR4,TNFRSF11A,TNFRSF1A,TNFSF11,H2-DMA,H2-DMB1,H2BFM,HADH,HNF1A,HPSE,HSPD1,HTT,ICA1,IFNGR2,IKBKG,IL12B,IL1R1,IL2,ILDR2,INPP5K,INPPL1,INSR,IRAK1,IRF1,IRS3,JAK2,KCNJ11,KHK,KRAS,LARS,LEP,LEPR,LEPROT,LIPE,LMAN1L,LPIN1,LTA, MAP3K7,MAPK8,MYD88,MYO5A,NCK1,NFKB1,NFKB2,NFKBIB,NFKB1,NFKB2,NFKBIB,RELA |
| myocardial infarction | 6.49E-12 | AKT1,AKT1,APP,CNR1,CREB1,CTNNB1,DRD2,EP300, ERK1/2,FOS,HDAC2,HDAC3,KL,LEP,MAPK1, MAPK3,NPY,NR3C1,STAT3,THRB,GPX3, SRC |
| hypertrophy of cardiomyocytes | 6.16E-06 | AKT1,EP300,HDAC2,LEP,MAPK1,PI3K (complex), STAT3 |
| coronary artery disease | 3.08E-04 | APOE, CNR1,FOS,HDAC2,KL,NR3C1, LEP |
| metabolic disorders: types I and II diabetes | 3.78E-15 | AANAT,ABCC8,ACLY,ACSBG1,ACSBG2,ACSL4,ACSL6,ACVR1C,ADCY8,ADIPOR1,ADIPOR2,AGRP,AKT1,ANXA1,APAF1,APOE,ASIC2,ATM,BAD,BCAR1,CACNA1C,CAMP,CAPN8,CASP3,CBL,CCKAR,CD247,CDK2,CEBPB,CERK,CHUK,CITED1,CNR1,CNR2,CPE,CPLX3,GAD2,GCK,GH,GHRHR,GHRL,GHSR,GLP1R,GPR119,GRB2,GSK3B,GYS1,GZMB,H2DMA,H2DMB1,H2Q1,H2BFM,HADH,HNF1A,HPSE,HSPD1,HTT,ICA1,IFNGR2,IKBKG,ILDR2,INPP5K,INPPL1,INSR,IRAK1,IRS3,JAK2,KCNJ11,KHK,KRAS,LARS,LEP,LEPR,LEPROT,LIPE,LMAN1L,LPIN1,LTA,MAP2K2,MAP3K7,MAPK8,MC4R,MRAS,MTOR,MYO5A,NCK1,NGFR,NOS2,NPY,NRAS,NSMAF,OCRL,PAK1,SGK1,SH2B2,SIK2,SLC2A4,SLC2A8,SLC30A8,SMAD2,SOCS1,SORBS1,SORT1,SOS1,SOS2,SRC,STAT1,STAT3,STX1A,STXBP4,SYNJ2,SYP,TLN1,TLN2,TRADD,TRAF6,TRIB3,TRIP10,TSC1,TSC2,VAMP2,VDR,WDTC1,ZFP106 |
| weight gain and obesity | 4.33E-10 | APP,BDNF,CNR1,CRH,DRD2,FOS,LEP,NPY,NTRK2, STAT3,CRK,CYB5R4,CYP27B1,DGAT1,DOK4,EGR1,EIF2AK3,EIF4EBP2,ENPP7,FADD,FAM3B,FAS,FASL,FCER1G,FFAR1,FKBP1B,FOXC2,FOXO4,FRS3,FYN,GAB1,PCLO,PCSK9,PDE3B,PDIA3,PDK1,PDPK1,PDX1,PHIP,PIAS1,PIK3C2G,PIK3CG,PIK3R5,PKLR,PKM,PLCB2,PLCZ1,PPARG,PPP1R3D,PRF1,PRKAR2B,PRKCD,PTEN,PTPN2,PTPRA,RAF1,RAPGEF4,RBP4,RELA,RETN,RHOQ,RIMS2,RIPK1,RPE65,RPS6KB2,RPTOR,RRAS2,SCAP,SCNN1G, |