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. 2015 Feb 21;14:47. doi: 10.1186/s12943-015-0320-6

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© Li et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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ITLN1 facilitates the expression of KLF4 via inactivation of PI3K/AKT signaling. (A) Western blot showing the phosphorylation of AKT (T308 and S473) and expression of KLF4 in solvent (mock)- or recombinant ITLN1-treated SH-SY5Y (1 and 2 μg/ml for 24 hrs) and SK-N-BE(2) (1 μg/ml for 24 and 36 hrs) cells. (B) Western blot showing the phosphorylation of AKT (T308 and S473) and expression of KLF4 in NB cells stably transfected with sh-Scb or sh-ITLN1, and those pre-treated with LY294002 (10 μmol/L).