Table 1.
Synopsis of cases
| Control | Alzheimer’s disease | |||||
|---|---|---|---|---|---|---|
| Preclinical AD | Prodromal AD/MCI | AD mild dementia | AD moderate dementia | AD severe dementia | ||
| Number of cases | 19 | 18 | 13 | 18 | 22 | 30 |
| Gender: male/female | 8/11 | 7/11 | 6/7 | 8/10 | 9/13 | 12/18 |
| Age in years (+/-SD) | 81.3 +/- 4.4 | 79.9 +/- 6.5 | 80.2 +/- 5.4 | 81.4 +/- 5.9 | 83.6 +/- 5.8 | 83.4 +/- 6.8 |
| CDR | ||||||
| 0 | 19 | 18 | ||||
| 0.5 | 13 | |||||
| 1 | 18 | |||||
| 2 | 22 | |||||
| 3 | 30 | |||||
| NFT stage* | ||||||
| 0 | 19 | |||||
| 1 | 18 | 6 | ||||
| 2 | 7 | 6 | 4 | |||
| 3 | 12 | 18 | 30 | |||
| Aß/amyloid plaque score* | ||||||
| 0 | 19 | |||||
| 1 | 18 | 5 | ||||
| 2 | 8 | 4 | 2 | |||
| 3 | 14 | 20 | 30 | |||
| CERAD* | ||||||
| 0 | 19 | |||||
| 1 | 18 | 4 | ||||
| 2 | 9 | 5 | 2 | |||
| 3 | 13 | 20 | 30 | |||
| ABC score* | ||||||
| Not | 19 | |||||
| Low | 18 | 7 | ||||
| Intermediate | 6 | 6 | 4 | |||
| High | 12 | 18 | 30 | |||
| Cause of death | ||||||
| Bronchopneumonia | 5 | 15 | 10 | 12 | 16 | 25 |
| Myocardial infarction | 8 | |||||
| Congestive heart failure | 1 | 1 | 1 | 2 | ||
| Embolism of lung | 3 | 3 | 1 | 2 | 1 | 2 |
| Sepsis | 1 | 2 | 3 | 1 | ||
| Lung cancer | 1 | 1 | ||||
| Pancreatic cancer | 1 | |||||
| Breast cancer | 1 | |||||
| Renal failure | 1 | |||||
| Postmortem delay in h (+/-SD) | 3.4 +/- 0.6 | 3.8 +/- 0.7 | 4.1 +/- 0.5 | 3.5 +/- 0.6 | 3.7 +/- 0.7 | 3.6 +/- 0.8 |
| Fresh brain weight in gm (+/-SD) | 1278 +/- 76 | 1258 +/- 51 | 1245 +/- 86 | 1212 +/- 56 | 1183 +/- 64 | 1150 +/- 103 |
| Phospho-tau (mab AT8) positive pathology | ||||||
| Ncl basalis of Meynert | 0 | 18 | 13 | 18 | 22 | 30 |
| Locus coeruleus | 0 | 18 | 13 | 18 | 22 | 30 |
| Entorhinal cort. Layer II | 0 | 18 | 13 | 18 | 22 | 30 |
| Aß (mab 6E10) positive pathology | ||||||
| Ncl basalis of Meynert | 0 | 0 | 8 | 18 | 22 | 30 |
| Locus coeruleus | 0 | 0 | 0 | 14 | 20 | 30 |
| Entorhinal cort. Layer II | 0 | 6 | 10 | 18 | 22 | 30 |
*according to [64].