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. 2015 Mar 12;8:11. doi: 10.1186/s12920-015-0086-0

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© Varn et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The GSAS of VANTVEER_BREAST_CANCER_METASTASIS_DN predicts patient survival. (A) The distribution of genes from this gene set in an expression-ranked gene list in samples with a low (Sample X), intermediate (Sample Y), and high (Sample Z) GSAS. (B) The distribution of GSASs across all samples in a dataset. (C) Patients with positive GSASs (red curve) show significantly shorter survival times than those with negative GSASs (green curve). Vertical hash marks indicate points of censored data. (D) In a Cox PH model, this GSAS significantly predicts patient survival even after adjusting for traditional clinical features. A red dotted line indicates where the hazard ratio = 1.