Table 1.
Demographics and transplant data
| Pathologic diagnosis | ATN | AR | CIN | IF/TA | P |
|---|---|---|---|---|---|
| Number of biopsies | 9 | 43 | 9 | 20 | |
| Age (years) | 41 (40–56)1 | 41 (28–51) | 36 (33–54) | 39 (30–49) | 0.942 |
| Gender (male/female) | 4/5 | 15/28 | 3/6 | 10/10 | 0.644 |
| Ethnicity (caucasian/non-caucasian) | 7/2 | 39/4 | 8/1 | 18/2 | 0.495 |
| Donor (deceased/living) | 8/1 | 26/17 | 5/4 | 14/6 | 0.144 |
| Donor age (years) | 61 (42–63) | 47 (41–51) | 47 (33–68) | 52 (48–52) | 0.248 |
| Induction (Basiliximab/Thymoglobulin) | 2/2 | 11/3 | 3/0 | 8/1 | 0.573 |
| Serum creatinine2,3 (mg/dL) | 7.3 (5.1-8.0) | 4.3 (2.4-5.9) | 1.9 (1.7-2.3) | 3.3 (2.3-4.5) | <0.05 |
| Cold ischemia time (hr) | 21 (20–26) | 16 (11–22) | 19 (12–21) | 16 (13–18) | <0.05 |
| Time to biopsy4 (days) | 27 (14–84) | 13 (9–49) | 31 (18–226) | 569 (227–1223) | <0.05 |
ATN = acute tubular necrosis; AR = acute rejection; CIN = calcineurin inhibitor nephrotoxicity; IF/TA = interstitial fibrosis and tubular atrophy.
1Median and interquartile range; 2At biopsy; 3Kruskall Wallis (AR > CIN and ATN > AR and IF/TA); 4Kruskall Wallis (IF/TA > ATN and AR).