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. 2015 Jan 31;3:6. doi: 10.1186/s40478-014-0182-y

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© Rothaug et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Neuropathological changes in the absence of LAMP-2 expression. Representative histological brain sections from LAMP-2-deficient (LAMP-2^-/y) mice and their wild-type (WT) littermates (zoomed images shown in insets). (a) Astrogliosis in LAMP-2^-/y brain visualized with the aid of GFAP immunological staining. (b) Immunoblotting of brain lysates showing GFAP expression levels in WT and in LAMP-2^-/y brain tissue. (c) Microgliosis observed in LAMP-2^-/y animals via CD68 immunological staining (sections were costained with Nissl).