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. 2015 Jan 31;3:6. doi: 10.1186/s40478-014-0182-y

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© Rothaug et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Abnormal behavior as a result of LAMP-2 deficiency in mice. (a) LAMP-2-deficient (LAMP-2^-/y) mice show a significantly reduced paw area at the peak of stance in comparison with wild-type mice. (b) LAMP-2^-/y mice swim significantly slower than wild-type controls. (c) Path length during exploration of a novel environment is significantly reduced in LAMP-2^-/y mice. (d) Freezing percentage is significantly increased in LAMP-2^-/y mice during the habituation phase. There was no difference in fear conditioning and contextual or cued fear memory. (e) Y-maze working memory: LAMP-2^-/y mice make significantly less spontaneous alternations (*p < 0.05; **p < 0.01).