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. 2015 Jan 31;3:6. doi: 10.1186/s40478-014-0182-y

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© Rothaug et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Abnormal lysosomal activity in the absence of LAMP-2 expression. (a) Immunoblots and respective densitometric quantification of cathepsin D (CtD) in wild-type (WT) or LAMP-2-deficient (LAMP-2^-/y) brain lysates (data are shown as the mean; protein levels were normalized to actin, asterisk highlights a non-specific band recognized by the used cathepsin D antibody and p (premature), i (intermediate) and m (mature) denote the different forms of cathepsin D). (b/c) Regional specific activity of (b) β-hexosaminidase and (c) β-glucuronidase in wild-type and LAMP-2^-/y brain lysates (Hip, hippocampus; Cx, cortex; Cblm, cerebellum; ^#p > 0.05, *p < 0.05).