Table 2.
Lifetime risk of developing heart failure in 7,495 men by body mass index (BMI) with or without ischemic heart disease
| Number at risk | HF events | Observation years | Incidence rate per 1000 observations years | Age adjusted SHR | Multivariable adjusted a SHR | Multivariable adjusted b SHR | |
|---|---|---|---|---|---|---|---|
| n = 7494 | (95% CI) | (95% CI) | (95% CI) | ||||
| All HF events (n = 1855) | |||||||
| BMI | |||||||
| <22.5 | 1182 | 234 | 29473 | 7.94 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) |
| 22.5-24.99 | 2266 | 533 | 59057 | 9.03 | 1.20 (1.02-1.39) | 1.19 (1.02-1.39) | 1.16 (0.99-1.36) |
| 25-27.49 | 2222 | 562 | 57564 | 9.76 | 1.29 (1.11-1.50) | 1.30 (1.11-1.52) | 1.26 (1.07-1.47) |
| 27.5-29.9 | 1207 | 342 | 29864 | 11.45 | 1.50 (1.27-1.77) | 1.51 (1.28-1.79) | 1.44 (1.21-1.71) |
| ≥30 | 617 | 184 | 13976 | 13.17 | 1.62 (1.33-1.97) | 1.61 (1.32-1.96) | 1.51 (1.23-1.85) |
| HF without IHD (n = 851) | |||||||
| BMI | |||||||
| <22.5 | 1182 | 117 | 29888 | 3.91 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) |
| 22.5-24.99 | 2266 | 251 | 60084 | 4.18 | 1.11 (0.89-1.38) | 1.08 (0.87-1.35) | 1.11 (0.88-1.38) |
| 25-27.49 | 2222 | 247 | 58580 | 4.22 | 1.11 (0.89-1.38) | 1.10 (0.89-1.37) | 1.14 (0.91-1.43) |
| 27.5-29.9 | 1207 | 153 | 30603 | 5.00 | 1.28 (1.01-1.63) | 1.28 (1.00-1.63) | 1.38 (1.07-1.77) |
| ≥30 | 617 | 83 | 14352 | 5.78 | 1.39 (1.05-1.84) | 1.39 (1.04-1.85) | 1.52 (1.13-2.04) |
| HF and IHD (n = 1004) | |||||||
| BMI | |||||||
| <22.5 | 1182 | 117 | 29785 | 3.93 | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) |
| 22.5-24.9 | 2266 | 282 | 59844 | 4.71 | 1.26 (1.02-1.57) | 1.28 (1.02-1.58) | 1.20 (0.97-1.50) |
| 25-27.49 | 2222 | 315 | 58386 | 5.40 | 1.44 (1.17-1.79) | 1.47 (1.18-1.83) | 1.34 (1.07-1.67) |
| 27.5-29.9 | 1207 | 189 | 30440 | 6.21 | 1.62 (1.29-2.04) | 1.65 (1.30-2.08) | 1.43 (1.12-1.81) |
| ≥30 | 617 | 101 | 14354 | 7.04 | 1.72 (1.32-2.25) | 1.69 (1.29-2.23) | 1.41 (1.07-1.86) |
aAdjusted for age, IHD, smoking, physical activity and occupational status.
bAdjusted for age, IHD, smoking, physical activity, occupational class, total serum cholesterol, diabetes, systolic blood pressure and hypertension.
cIHD defined as acute myocardial infarction or revascularization (coronary artery bypass grafting (CABG) or percutaneus coronary intervention (PCI)).
HF indicates heart failure; BMI, body mass index; SHR, subdistribution hazard ratio and IHD, ischemic heart disease.