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Toxicity differences between the two protocols
| Modified-BFM-95 | BFM-95 | P value | ||||||
| Total | 31 | 23 | ||||||
| Stage 4 myelosupression | 31 | 100% | 23 | 100% | ||||
| Coagulation defects | Grade 2 | 4 | 12.9% | Grade 2 | 2 | 8.7% | 0.627 | |
| Grade 3 | 1 | 3.2% | Grade 3 | - | - | 0.385 | ||
| Anaphylactic reaction | Grade 3 | 1 | 3.2% | Grade 3 | 5 | 21.7% | 0.032 | |
| Grade 4 | - | - | Grade 4 | 1 | 4.3% | 0.241 | ||
| Pancreatitis | Grade 2 | 2 | 6.5% | Grade 2 | 2 | 8.7% | 0.756 | |
