Table 1. Hemodynamic Evaluation.
| CPR | ROSC | |||||||
|---|---|---|---|---|---|---|---|---|
| Baseline | 3min | 5min | 8min | 10min | 30 min | 60 min | ||
| SBP | ACD-ITD | 100 ± 2 | 86 ± 7 | 108 ± 9 | 95 ± 7 | 108 ± 11 | 97 ± 4 | 97 ± 4 |
| SNPeCPR+EPI | 102 ± 6 | 71 ± 5 | 84 ± 8 | 85 ± 8 | 99 ± 11 | 99 ± 6 | 101 ± 3 | |
| SNPeCPR | 111 ± 7 | 78 ± 6 | 89 ± 7 | 90 ± 6 | 89 ± 7 | 87 ± 7 | 83 ± 9 | |
|
| ||||||||
| DBP | ACD-ITD | 65 ± 2 | 27 ± 2 | 40 ± 4 | 34 ± 4 | 42 ± 6 | 63 ± 5 | 62 ± 4 |
| SNPeCPR+EPI | 67 ± 5 | 23 ± 4 | 28 ± 2§ | 30 ± 3 | 40 ± 5 | 60 ± 6 | 61 ± 3 | |
| SNPeCPR | 77 ± 5 | 24 ± 2 | 23 ± 3* | 27 ± 2 | 27 ± 1 | 56 ± 4 | 54 ± 7 | |
|
| ||||||||
| RA | ACD-ITD | 2 ± 1 | 3 ± 1 | 4 ± 1 | 4 ± 1 | 4 ± 1 | 5 ± 1 | 4 ± 1 |
| SNPeCPR+EPI | 1 ± 1 | 2 ± 1 | 3 ± 1 | 3 ± 1 | 4 ± 1 | 4 ± 1 | 4 ± 1 | |
| SNPeCPR | 0 ± 1 | 3 ± 1 | 3 ± 1 | 4 ± 1 | 3 ± 1 | 6 ± 1 | 3 ± 1 | |
|
| ||||||||
| CBF | ACD-ITD | 263 ± 23 | 36 ± 5 | 31 ± 7 | 42 ± 5 | 26 ± 7 | 119 ± 31 | 184 ± 33 |
| SNPeCPR+EPI | 247 ± 39 | 74 ± 8§ | 46 ± 6 | 61 ± 7 | 35 ± 5 | 161 ± 32 | 157 ± 24 | |
| SNPeCPR | 338 ± 43 | 90 ± 15* | 103 ± 18*, # | 90 ± 15* | 83 ± 15*, # | 76 ± 12 | 102 ± 20 | |
|
| ||||||||
| ICP | ACD-ITD | 23 ± 1 | 30 ± 2 | 34 ± 3 | 28 ± 2 | 29 ± 2 | 14 ± 1 | 16 ± 2 |
| SNPeCPR+EPI | 21 ± 2 | 31 ± 3 | 31 ± 3 | 36 ± 3 | 31 ± 4 | 15 ± 2 | 15 ± 2 | |
| SNPeCPR | 20 ± 2 | 32 ± 2 | 34 ± 3 | 29 ± 2 | 34 ± 2 | 14 ± 1 | 14 ± 1 | |
|
| ||||||||
| CPP | ACD-ITD | 63 ± 2 | 25 ± 2 | 37 ± 3 | 30 ± 4 | 38 ± 5 | 58 ± 5 | 59 ± 5 |
| SNPeCPR+EPI | 66 ± 5 | 21 ± 4 | 25 ± 2 | 27 ± 3§ | 35 ± 5 | 56 ± 6 | 57 ± 3 | |
| SNPeCPR | 77 ± 5 | 20 ± 2 | 20 ± 3 | 23 ± 3* | 24 ± 2 | 50 ± 5 | 50 ± 7 | |
|
| ||||||||
| CePP | ACD-ITD | 59 ± 2 | 17 ± 4 | 29 ± 7 | 23 ± 6 | 30 ± 8 | 54 ±10 | 51 ±9 |
| SNPeCPR+EPI | 53 ± 3 | 13 ± 4 | 21 ± 3 | 17 ± 4 | 26 ± 5 | 54 ± 3 | 60 ± 3 | |
| SNPeCPR | 72 ± 6# | 14 ± 3 | 15 ± 3 | 14 ± 3 | 15 ± 5 | 56 ± 6 | 54 ± 8 | |
|
| ||||||||
| ETCO2 | ACD-ITD | 41 ± 1 | 38 ± 4 | 37 ± 3 | 28 ± 2 | 27 ± 2 | 44 ± 1 | 40 ± 1 |
| SNPeCPR+EPI | 40 ± 1 | 41 ± 2 | 39 ± 2 | 36 ± 3§ | 31 ± 2 | 45 ± 1 | 41 ± 1 | |
| SNPeCPR | 39 ± 1 | 32 ± 3 | 28 ± 2# | 29 ± 2 | 25 ± 4 | 36 ± 3*, # | 36 ± 3 | |
SBP = Systolic Blood Pressure, DBP = Diastolic Blood Pressure, RA = Diastolic Right Atrial Pressure, CBF = Carotid Blood Flow, ICP = Intracranial Pressure, CPP = Coronary Perfusion Pressure, CePP = Cerebral Perfusion Pressure. ACD-ITD = Active Compression Decompression with Impedance Threshold Device, SNPeCPR = Sodium Nitroprusside enhanced CPR and EPI = Epinephrine. Values are shown as mean ± SEM. Pressures are presented in mm Hg and flow in ml/min.
*
denotes p < 0.05 comparing SNPeCPR and ACD-ITD alone.
#
denotes p < 0.05 comparing SNPeCPR and SNPeCPR+EPI.
§
denotes p < 0.05 comparing SNPeCPR+EPI and ACD-ITD alone.