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Histopathology and immunohistochemical staining for avian influenza virus antigen in tissues of chickens intravenously infected with the A/Anhui/1/2013 H7N9 virus, 3 DPI. Photomicrographs, magnification 100-400X; virus staining in brown. A-F. Kidney. Severe lymphocytic tubulointerstitial nephritis with necrosis of tubular epithelium and tubular cast (arrows)(A and B). Demonstration of viral antigen in tubule epithelium, infiltrating mononuclear cells, and debri (C-F).
