Table 1.
Clinical characteristics of the ischemic stroke cohort (n=1008).
| PEOS n = 249 |
PAASO n = 448 |
PLOS n = 311 |
All n = 1008 |
|
|---|---|---|---|---|
| Age, y, mean (SD) | 46.1 (7.5) | 65.4 (5.7) | 82.3 (5.1) | 65.9 (14.7) |
| Male sex, n (%) | 170 (68.3) | 311 (69.4) | 141 (45.3) | 622 (61.7) |
| WMHv,* cm3, median (IQR) | 2.4 (1.5 – 4.0) | 6.1 (3.1 – 12.0) | 11.3 (6.2 – 23.0) | 6.0 (2.7 – 12.5) |
| Normalized WMHv,† mean (SD) | 0.9 (0.9) | 1.8 (1.0) | 2.4 (1.0) | 1.8 (1.1) |
| Creatinine, mg/dL, median (IQR) | 0.9 (0.8 – 1.1) | 1.0 (0.9 – 1.2) | 1.0 (0.9 – 1.3) | 1.0 (0.8 – 1.2) |
| Risk Factors, n (%) | ||||
| HTN | 98 (39.4) | 310 (69.2) | 250 (80.4) | 658 (65.3) |
| T2DM | 41 (16.5) | 109 (24.3) | 60 (19.3) | 210 (20.8) |
| HL | 71 (28.5) | 222 (49.6) | 154 (49.5) | 447 (44.3) |
| AF | 14 (5.6) | 55 (12.3) | 97 (31.2) | 166 (16.5) |
| CAD | 18 (7.2) | 94 (21.0) | 88 (28.3) | 200 (19.8) |
| Alcohol use | 123 (49.4) | 231 (51.6) | 154 (49.5) | 508 (50.4) |
| History of tobacco use | 142 (57.0) | 311 (69.4) | 165 (53.1) | 618 (61.3) |
| Prior TIA | 13 (5.2) | 34 (7.6) | 29 (9.3) | 76 (7.5) |
| Prior AIS | 28 (11.2) | 80 (17.9) | 52 (16.7) | 160 (15.9) |
| Race | ||||
| White | 219 (88.0) | 413 (92.2) | 294 (94.5) | 926 (91.9) |
| Black | 13 (5.2) | 25 (5.6) | 7 (2.3) | 45 (4.5) |
| Asian | 6 (2.4) | 4 (0.9) | 3 (1.0) | 13 (1.3) |
| Native American | 1 (0.4) | 0 (0.0) | 0 (0.0) | 1 (0.1) |
| Multiple | 4 (1.6) | 1 (0.2) | 1 (0.3) | 6 (0.6) |
| Other | 4 (1.6) | 3 (0.7) | 2 (0.6) | 9 (0.9) |
PEOS – patients with early-onset stroke; PAASO – patients with average age of stroke onset; PLOS – patients with late-onset stroke; SD – standard deviation; WMHv – white matter hyperintensity volume; IQR – interquartile range; HTN – hypertension; T2DM – type II diabetes mellitus; HL – hyperlipidemia; AF – atrial fibrillation; CAD – coronary artery disease; TIA – transient ischemic attack; AIS – acute ischemic stroke.
*
Adjusted for head size.
†
Adjusted for head size and natural log-transformed.