Table 2.

Predictors of white matter hyperintensity volume^* in ischemic stroke cohort.

	PEOS n = 249		PAASO n = 448		PLOS n = 311		All n = 1008
	β	p-value	β	p-value	β	p-value	β	p-value
Age	0.02	0.002	0.05	8.36×10−8	0.02	0.106	0.04	9.55×10−75
Male sex	0.13	0.300	0.04	0.662	−0.25	0.023	−0.23	0.002
Creatinine	−0.09	0.433	0.25	0.024	−0.18	0.085	0.16	0.034
HTN	0.34	0.004	0.19	0.063	0.07	0.599	0.56	8.92×10−15
T2DM	0.29	0.062	0.11	0.328	−0.07	0.634	0.13	0.119
HL	0.21	0.093	−0.17	0.080	−0.26	0.015	0.07	0.323
AF	0.09	0.718	0.17	0.226	0.13	0.277	0.51	5.90×10−8
CAD	0.42	0.060	0.25	0.033	−0.25	0.037	0.34	0.0001
Alcohol use	0.20	0.084	0.23	0.015	0.23	0.035	0.24	0.0009
History of tobacco use	0.44	0.0001	0.12	0.231	−0.18	0.111	0.10	0.190
Prior TIA	−0.16	0.541	−0.35	0.049	0.17	0.356	0.003	0.979
Prior AIS	0.04	0.817	0.34	0.006	0.12	0.409	0.30	0.002
Non-white race	−0.13	0.483	−0.32	0.077	−0.49	0.072	−0.49	0.0002

PEOS – patients with early-onset stroke; PAASO – patients with average age of stroke onset; PLOS – patients with late-onset stroke; HTN – hypertension; T2DM – type II diabetes mellitus; HL – hyperlipidemia; AF – atrial fibrillation; CAD – coronary artery disease; TIA – transient ischemic attack; AIS – acute ischemic stroke

^*Natural log-transformed.