Table 3.

Multivariable linear regression model predictors of white matter hyperintensity volume^* in ischemic stroke cohort.

	PEOS n = 242		PAASO n = 440		PLOS n = 292		All n = 974
	β	p-value	β	p-value	β	p-value	β	p-value
Age	0.02	0.018	0.05	1.19×10−8			0.04	2.88×10−58
Male sex					−0.30	0.007
Creatinine			0.27	0.011
HTN	0.24	0.049	0.22	0.037			0.22	0.002
T2DM
HL			−0.23	0.016	−0.27	0.015	−0.17	0.008
AF
CAD			0.19	0.098
Alcohol use	0.19	0.086	0.18	0.046	0.23	0.034	0.23	9.82×10−5
History of tobacco use	0.38	0.001					0.11	0.075
Prior TIA			−0.41	0.017
Prior AIS			0.24	0.040			0.18	0.029
Non-white race			−0.34	0.048	−0.49	0.065	−0.24	0.034

PEOS – patients with early-onset stroke; PAASO – patients with average age of stroke onset; PLOS – patients with late-onset stroke; HTN – hypertension; T2DM – type II diabetes mellitus; HL – hyperlipidemia; AF – atrial fibrillation; CAD – coronary artery disease; TIA – transient ischemic attack; AIS – acute ischemic stroke

^*Natural log-transformed.