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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Biol Blood Marrow Transplant. 2015 Jan 10;21(4):761–767. doi: 10.1016/j.bbmt.2015.01.001

Table 4.

GVHD Risk Definition by Organ Stage at Onset

GVHD Risk Score One Organ (n) Two Organs (n) Three Organs (n)
Standard Risk (N=1454, 84%) Stage 1–3 Skin (901) Stage 1–3 Skin plus Stage 1 GI (223)† --
Stage 1–2 GI (279)** Stage 1–3 Skin plus Stage 1–4 Liver (51) --
High Risk* (N=269, 16%) Stage 4 Skin (13) Stage 1–3 Skin plus Stage 2 GI (54) Stage 1–3 Skin plus Stage 1–2 GI plus Stage 1–3 Liver (23)
Stage 3–4 GI (74)†† Stage 1–2 Lower GI plus Stage 1–3 Liver (12) Stage 1–3 Skin plus Stage 3–4 GI plus Stage 1–4 Liver (13)
Stage 1–4 Liver (25)*** Stage 3–4 GI plus Stage 1–3 Skin (45)
Stage 3–4 GI plus Stage 1–4 Liver (10)

UGI plus Lower GI considered as single organ disease

*

For high risk disease, the degree of organ involvement is the minimum necessary to be deemed high risk. Patients with higher stage of GVHD than observed in the high-risk group should also be considered high risk.

**
Stage 1–2 GI includes:
  • UGI alone (n=115)
  • Stage 1–2 Lower GI alone (100)
  • UGI and Stage 1 Lower GI (64)
††
Stage 3–4 GI includes:
  • Stage 3 Lower GI alone (65)
  • Stage 4 Lower GI alone (9)
***
Stage 1–4 Liver includes:
  • Stage 1 Liver alone (7)
  • Stage 2 Liver alone (10)
  • Stage 3 Liver alone (5)
  • Stage 4 Liver alone (3)
†
Stage 1–3 Skin plus Stage 1 GI includes:
  • Stage 1–3 Skin plus UGI (90)
  • Stage 1–3 Skin plus Stage 1 Lower GI (71)
  • Stage 1–3 Skin plus UGI and Stage 1 Lower GI (62)