Table 2. Ratio of observed to expected cases (O/E) of risk of new invasive cancer according to interval post-transplant.
| Time since transplant | |||||||||
|---|---|---|---|---|---|---|---|---|---|
|
|
|||||||||
| < 1 year | 1-2 year | 3-5 year | |||||||
| N subjects | 4161 | 3464 | 2578 | ||||||
| Person-years in risk | 3849 | 3003 | 4608 | ||||||
|
| |||||||||
| New Cancer Site and ICD-O Code | O | O/E | 99% CI | O | O/E | 99% CI | O | O/E | 99% CI |
|
| |||||||||
| Nasopharynx C11 | 1 | 22.33 | 0.11-165.91 | 0 | 0.00 | 0.00-147.26 | 1 | 17.48 | 0.09-129.85 |
| Esophagus C15 | 0 | 0.00 | 0.00-10.43 | 0 | 0.00 | 0.00-12.49 | 2 | 2.85 | 0.15-13.20 |
| Colon C18 | 2 | 0.71 | 0.04-3.30 | 2 | 0.84 | 0.04-3.88 | 2 | 0.50 | 0.03-2.31 |
| Rectum C19.20 | 0 | 0.00 | 0.00-3.95 | 1 | 0.90 | 0.004-6.66 | 1 | 0.54 | 0.003-4.04 |
| Liver C22 | 0 | 0.00 | 0.00-11.34 | 0 | 0.00 | 0.00-13.75 | 2 | 3.18 | 0.16-14.75 |
| Pancreas C25 | 0 | 0.00 | 0.00-5.89 | 2 | 2.63 | 0.14-12.20 | 1 | 0.79 | 0.004-5.84 |
| Trachea, bronchus, lung C33 | 2 | 0.31 | 0.02-1.43 | 2 | 0.36 | 0.02-1.68 | 7 | 0.76 | 0.22-1.85 |
| Other thoracic organs C37 | 0 | 0.00 | 0.00-168.71 | 0 | 0.00 | 0.00-207.75 | 0 | 0.00 | 0.00-129.04 |
| Melanoma C43 | 4 | 2.81 | 0.47-8.84 | 8 | 6.91 | 2.22-16.04 | 3 | 1.61 | 0.18-5.88 |
| Other skin C44 | 4 | N/A | 4 | N/A | 5 | N/A | |||
| Soft tissue C47 | 1 | 4.86 | 0.02-1.89 | 1 | 5.91 | 0.03-43.92 | 1 | 3.63 | 0.02-26.95 |
| Breast C50 | 2 | 0.41 | 0.02-1.89 | 0 | 0.00 | 0.00-1.31 | 5 | 0.78 | 0.17-2.21 |
| Uterus C55 | 0 | 0.00 | 0.00-277.49 | 0 | 0.00 | 0.00-336.64 | 0 | 0.00 | 0.00-211.21 |
| Ovary C56 | 2 | 3.98 | 0.21-18.44 | 0 | 0.00 | 0.00-12.72 | 0 | 0.00 | 0.00-7.89 |
| Prostate C61 | 3 | 0.30 | 0.03-1.10 | 9 | 1.07 | 0.37-2.37 | 6 | 0.43 | 0.11-1.11 |
| Kidney C64 | 1 | 0.89 | 0.004-6.62 | 0 | 0.00 | 0.00-5.73 | 4 | 2.66 | 0.45-8.37 |
| Renal pelvis C65 | 1 | 17.53 | 0.09-130.25 | 0 | 0.00 | 0.00-108.42 | 0 | 0.00 | 0.00-63.46 |
| Ureter C66 | 0 | 0.00 | 0.00-152.01 | 1 | 33.15 | 0.17-246.27 | 0 | 0.00 | 0.00-102.03 |
| Bladder C67 | 1 | 0.55 | 0.002-4.05 | 0 | 0.00 | 0.00-3.38 | 0 | 0.00 | 0.00-1.99 |
| Nervous system C70.72 | 0 | 0.00 | 0.00-11.42 | 1 | 2.63 | 0.01-19.59 | 1 | 1.63 | 0.01-14.37 |
| Thyroid C73 | 0 | 0.00 | 0.00-12.44 | 0 | 0.00 | 0.00-56.12 | 1 | 1.93 | 0.01-14.37 |
| Hodgkin disease C81 | 0 | 0.00 | 0.00-44.13 | 0 | 0.00 | 0.00-56.12 | 2 | 13.51 | 0.70-62.66 |
| Non-Hodgkin disease C82 | 1 | 0.67 | 0.003-4.97 | 0 | 0.00 | 0.00-4.27 | 2 | 0.98 | 0.05-4.54 |
| Lymphoid leukemia CC91 | 0 | 0.00 | 0.00-13.23 | 0 | 0.00 | 0.00-15.76 | 2 | 3.57 | 0.18-16.57 |
| AML | 0 | 0.00 | 0.00-13.49 | 0 | 0.00 | 0.00-16.02 | 4 | 7.23 | 1.22-22.77 |
| MDS | 3 | N/A | 5 | N/A | 12 | N/A | |||
|
| |||||||||
| Overall | 27 | 0.64 | 0.37-1.03 | 35 | 0.99 | 0.61-1.51 | 61 | 1.05 | 0.73-1.45 |
|
| |||||||||
| Overall (excluding ‘skin’) | 23 | 0.55 | 0.30-0.92 | 31 | 0.88 | 0.53-1.38 | 56 | 0.96 | 0.66-1.35 |
|
| |||||||||
| Time since transplant | |||||||||
|
|
|||||||||
| 6-10 | 11-20 | Overall | |||||||
|
| |||||||||
| Number of patients | 820 | 110 | 4161 | ||||||
|
| |||||||||
| Person-year in risk | 1769 | 158 | 13387 | ||||||
|
| |||||||||
| Secondary Cancer Site ICD –O code | O | O/E | 99% CI | O | O/E | 99% CI | O | O/E | 99% CI |
|
| |||||||||
| Nasopharynx | 0 | 0.00 | 0.00-238.08 | 0 | 0.00 | 0.00-2510.28 | 2 | 12.32 | 0.64-57.12 |
| Esophagus C15 | 1 | 3.39 | 0.02-25.18 | 0 | 0.00 | 0.00-180.73 | 3 | 1.53 | 0.17-5.60 |
| Colon C18 | 2 | 1.14 | 0.06-5.30 | 0 | 0.00 | 0.00-29.09 | 8 | 0.72 | 0.23-1.67 |
| Rectum C19.20 | 1 | 1.28 | 0.01-9.54 | 0 | 0.00 | 0.00-69.02 | 3 | 0.58 | 0.07-2.13 |
| Liver C22 | 0 | 0.00 | 0.00-20.77 | 0 | 0.00 | 0.00-209.09 | 2 | 1.14 | 0.06-5.26 |
| Pancreas C25 | 0 | 0.00 | 0.00-9.67 | 0 | 0.00 | 0.00-92.40 | 3 | 0.85 | 0.10-3.10 |
| Trachea, bronchus, lung C33 | 3 | 0.75 | 0.08-2.74 | 0 | 0.00 | 0.00-12.86 | 14 | 0.55 | 0.24-1.05 |
| Other thoracic organs C37 | 1 | 60.43 | 0.30-449.08 | 0 | 0.00 | 0.00-3318.32 | 1 | 8.61 | 0.04-63.98 |
| Melanoma C43 | 3 | 3.80 | 0.43-13.91 | 1 | 14.12 | 0.07-104.93 | 19 | 3.58 | 1.82-6.29 |
| Other skin C44 | 5 | N/A | 0 | N/A | 18 | N/A | |||
| Soft tissue C47 | 0 | 0.00 | 0.00-45.52 | 0 | 0.00 | 0.00-470.11 | 3 | 3.85 | 0.43-14.10 |
| Beast C50 | 3 | 1.12 | 0.13-4.12 | 0 | 0.00 | 0.00-19.38 | 10 | 0.55 | 0.20-1.17 |
| Uterus C55 | 1 | 97.29 | 0.49-722.91 | 0 | 0.00 | 0.00-4826.66 | 1 | 14.03 | 0.07-104.22 |
| Ovary C56 | 0 | 0.00 | 0.00-18.65 | 0 | 0.00 | 0.00-175.24 | 2 | 1.05 | 0.05-4.87 |
| Prostate C61 | 2 | 0.34 | 0.02-1.56 | 2 | 3.34 | 0.17-15.50 | 22 | 0.56 | 0.30-0.95 |
| Kidney C64 | 3 | 4.81 | 0.54-17.61 | 0 | 0.00 | 0.00-87.15 | 8 | 4.24 | 0.61-4.39 |
| Renal pelvis C65 | 0 | 0.00 | 0.00-142.68 | 0 | 0.00 | 0.00-1429.66 | 1 | 1.34 | 0.02-34.27 |
| Ureter C66 | 0 | 0.00 | 0.00-225.73 | 0 | 0.00 | 0.00-2218.64 | 1 | 7.00 | 0.04-52.02 |
| Bladder C67 | 1 | 0.84 | 0.004-6.21 | 0 | 0.00 | 0.00-46.09 | 2 | 0.27 | 0.01-1.26 |
| Nervous system C70.72 | 0 | 0.00 | 0.00-20.61 | 0 | 0.00 | 0.00-216.10 | 2 | 1.15 | 0.06-5.33 |
| Thyroid C73 | 0 | 0.00 | 0.00-25.97 | 0 | 0.00 | 0.00-276.57 | 1 | 0.67 | 0.003-4.94 |
| Hodgkin disease C81 | 0 | 0.00 | 0.00-91.85 | 0 | 0.00 | 0.00-1008.68 | 2 | 4.70 | 0.24-21.80 |
| Non-Hodgkin lymphoma C82 | 0 | 1.15 | 0.01-8.56 | 1 | 11.79 | 0.06-87.61 | 4 | 0.87 | 0.22-2.45 |
| Lymphoid leukemia C91 | 1 | 4.11 | 0.02-30.54 | 0 | 0.00 | 0.00-224.75 | 3 | 1.92 | 0.22-7.02 |
| AML | 2 | 8.28 | 0.43-38.41 | 2 | 83.14 | 4.30-385.50 | 8 | 5.19 | 1.67-12.04 |
| MDS | 6 | N/A | 1 | N/A | 27 | N/A | |||
|
| |||||||||
| Overall | 34 | 1.38 | 0.84-2.11 | 6 | 2.50 | 0.62-6.29 | 163 | 1.00 | 0.81-1.22 |
|
| |||||||||
| Overall (excluding ‘skin’) | 29 | 1.18 | 0.69-1.87 | 6 | 2.49 | 0.62-6.31 | 145 | 0.89 | 0.71-1.10 |
ICD-O refers to the International Classification of Diseases for Oncology;
Specific O/E ratios for MDS and “other skin cancers” not calculated – see methods section.