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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Biol Blood Marrow Transplant. 2014 Dec 31;21(4):738–745. doi: 10.1016/j.bbmt.2014.12.028

Table 6. Matched Cohort Analysis: Multivariate Odds ratio of developing new cancer comparing those who developed a new cancer vs. matched cohort of autotransplant recipients who did not.

Univariate Multivariate

Variable N OR (95% CI) P OR (95% CI) P

KPS: 90-100 vs 0-80% 456/280 1.37 (0.93-2.03) 0.11 ---- >0.10

BMI:
Normal 172 1.00 0.004b 1.00 0.020b
Overweight 340 1.02 (0.63-1.66) 0.94 1.22 (0.73-2.06) 0.519
Obesity 254 1.85 (1.14-2.98) 0.012 1.94 (1.15-3.26) 0.005

Smoker: Yes vs No 374/385 1.59 (1.10-2.29) 0.013 1.45 (0.99-2.12) 0.055

Lines of pre transplant therapy: >1 vs 1 284/485 1.20 (0.93-1.55) 0.165 1.32 (0.99-1.74) 0.053

Radiation: Yes vs No 208/561 1.07 (0.72-1.59) 0.739 --- >0.10

Thalidomide: Yes vs No 230/539 0.74 (0.48-1.14) 0.174 --- >0.10

Bortezomib: Yes vs No 108/661 0.94 (0.48-1.82) 0.845 --- >0.10

Lenalidomide: Yes vs No 53/716 0.99 (0.47-2.11) 0.985 --- >0.10

VAD: Yes vs No 369/400 1.34 (0.89-2.01) 0.158 --- >0.10

MP: Yes vs No 71/698 0.66 (0.33-1.32) 0.237 --- >0.10

Any Drug: Yes vs No 672/97 0.68 (0.41-1.11) 0.119 --- >0.10

Conditioning Regimen:
Melphalan alone 623 1.00 0.596c --- >0.10
TBI used 37 1.75 (0.74-4.14) 0.205
BU+CY 44 0.93 (0.41-2.09) 0.86
Others 72 0.96 (0.50-1.85) 0.9079
a

Thalidomide and Lenalidomide were not included in the model for fitting “Any Drug” effect.

b

2d.f. test

c

3 d.f. test