Table 6. Matched Cohort Analysis: Multivariate Odds ratio of developing new cancer comparing those who developed a new cancer vs. matched cohort of autotransplant recipients who did not.
Univariate | Multivariate | ||||
---|---|---|---|---|---|
| |||||
Variable | N | OR (95% CI) | P | OR (95% CI) | P |
| |||||
KPS: 90-100 vs 0-80% | 456/280 | 1.37 (0.93-2.03) | 0.11 | ---- | >0.10 |
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BMI: | |||||
Normal | 172 | 1.00 | 0.004b | 1.00 | 0.020b |
Overweight | 340 | 1.02 (0.63-1.66) | 0.94 | 1.22 (0.73-2.06) | 0.519 |
Obesity | 254 | 1.85 (1.14-2.98) | 0.012 | 1.94 (1.15-3.26) | 0.005 |
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Smoker: Yes vs No | 374/385 | 1.59 (1.10-2.29) | 0.013 | 1.45 (0.99-2.12) | 0.055 |
| |||||
Lines of pre transplant therapy: >1 vs 1 | 284/485 | 1.20 (0.93-1.55) | 0.165 | 1.32 (0.99-1.74) | 0.053 |
| |||||
Radiation: Yes vs No | 208/561 | 1.07 (0.72-1.59) | 0.739 | --- | >0.10 |
| |||||
Thalidomide: Yes vs No | 230/539 | 0.74 (0.48-1.14) | 0.174 | --- | >0.10 |
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Bortezomib: Yes vs No | 108/661 | 0.94 (0.48-1.82) | 0.845 | --- | >0.10 |
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Lenalidomide: Yes vs No | 53/716 | 0.99 (0.47-2.11) | 0.985 | --- | >0.10 |
| |||||
VAD: Yes vs No | 369/400 | 1.34 (0.89-2.01) | 0.158 | --- | >0.10 |
| |||||
MP: Yes vs No | 71/698 | 0.66 (0.33-1.32) | 0.237 | --- | >0.10 |
| |||||
Any Drug: Yes vs No | 672/97 | 0.68 (0.41-1.11) | 0.119 | --- | >0.10 |
| |||||
Conditioning Regimen: | |||||
Melphalan alone | 623 | 1.00 | 0.596c | --- | >0.10 |
TBI used | 37 | 1.75 (0.74-4.14) | 0.205 | ||
BU+CY | 44 | 0.93 (0.41-2.09) | 0.86 | ||
Others | 72 | 0.96 (0.50-1.85) | 0.9079 |
Thalidomide and Lenalidomide were not included in the model for fitting “Any Drug” effect.
2d.f. test
3 d.f. test