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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Neurosci Biobehav Rev. 2015 Jan 15;51:205–222. doi: 10.1016/j.neubiorev.2015.01.008

Table 1.

Predictions and evidence for compensation by declarative memory in neurodevelopmental disorders.

Predictions Evidence

SLI Dyslexia Autism Spectrum Disorder Tourette syndrome OCD
Increased reliance (from either spontaneous learning or therapy) on strategies thought to depend on declarative memory Habit reversal therapy, which involves the explicit control of tics, is effective in TS (Frank and Cavanna, 2013; Himle et al., 2006) Habit reversal therapy, as well as other cognitive behavioral therapies, are effective in OCD (March, 1995; Watson and Rees, 2008)

Increased reliance on the neural system underlying declarative memory Electrophysiological evidence: N400 ERP components found for grammatical processing (Fonteneau and van der Lely, 2008; Neville et al., 1993; Ullman and Pierpont, 2005) fMRI evidence: Increased activation in medial temporal lobe structures during some social processing tasks (Dichter et al., 2012; Vaidya et al., 2011) TBD fMRI and PET evidence: Increased activation in MTL structures (and decreased activation in the basal ganglia) during procedural memory and executive tasks (Rauch et al., 1997; Rauch et al., 2007; Rauch et al., 2001; Roth et al., 2003; van den Heuvel et al., 2005)

Indicators of better declarative memory are associated with better compensation Better grammatical abilities in individuals with better declarative memory (Lum et al., 2012) Better reading ability in individuals with better declarative memory and larger hippocampi/MTL structures (Hedenius et al., 2013; Krafnick et al., 2011) TBD OCD symptoms better in individuals with larger hippocampi/MTL structures (Carmona et al., 2007; Peterson et al., 2007; van den Heuvel et al., 2009)

Note. SLI: specific language impairment. TS: Tourette syndrome. OCD: obsessive-compulsive disorder. TBD: To be determined; we are not aware of any relevant studies. (f)MRI: (functional) magnetic resonance imaging. PET: positron emission tomography. ERP: event-related potential. MTL: medial temporal lobe.