Table 1.
FAS, 10-21, N = 17 | FAS, 22-34, N = 14 | FAS, 35-50, N = 8 | P value | |
---|---|---|---|---|
Clinical characteristics at presentation | ||||
Age (years) | 47 (40-61) | 52 (48-68) | 61 (50-70) | .08 |
Female gender, n (%) | 6 (35) | 8 (57) | 2 (25) | >.20 |
Initial NIHSS score | 3 (2-8) | 5 (4-10) | 7 (3-10) | .10 |
Infarct volume (mm3) | 3.8 (.5-15.0) | 4.4 (1.0-32.2) | .8 (.2-8.6) | >.20 |
Endorsed sadness,* n (%) | 3 (18) | 7 (50) | 5 (62) | <.05 |
Hypertension, n (%) | 8 (47) | 8 (57) | 4 (50) | >.20 |
Hyperlipidemia, n (%) | 13 (76) | 9 (64) | 7 (88) | >.20 |
Coronary heart disease, n (%) | 4 (24) | 1 (7) | 1 (12) | >.20 |
Atrial fibrillation, n (%) | 3 (18) | 4 (29) | 1 (12) | >.20 |
Diabetes mellitus, n (%) | 3 (18) | 3 (21) | 2 (25) | >.20 |
Smoker, n (%) | 8 (47) | 4 (29) | 2 (25) | >.20 |
Prior stroke on imaging, n (%) | 5 (29) | 3 (21) | 1 (12) | >.20 |
Genetic polymorphisms, n (%) | ||||
IL1RN rs4251961 (C/T or C/C genotype) | 7 (41) | 8 (57) | 7 (88) | .03 |
TLR4 299Gly/399Ile variant allele carriers | 4 (24) | 0 | 0 | .04 |
Abbreviations: FAS, Fatigue Assessment Scale; IL1RN, interleukin-1 receptor antagonist gene; NIHSS, National Institutes of Health Stroke Scale; TLR4, toll-like receptor-4 gene.
Endorsed sadness at any time point during the study likelihood ratio.