Table 1.
Differences in clinical characteristics and genetics in those who were not tired, those who were tired, and those who were extremely tired (based on the highest observed FAS score)
| FAS, 10-21, N = 17 | FAS, 22-34, N = 14 | FAS, 35-50, N = 8 | P value | |
|---|---|---|---|---|
| Clinical characteristics at presentation | ||||
| Age (years) | 47 (40-61) | 52 (48-68) | 61 (50-70) | .08 |
| Female gender, n (%) | 6 (35) | 8 (57) | 2 (25) | >.20 |
| Initial NIHSS score | 3 (2-8) | 5 (4-10) | 7 (3-10) | .10 |
| Infarct volume (mm3) | 3.8 (.5-15.0) | 4.4 (1.0-32.2) | .8 (.2-8.6) | >.20 |
| Endorsed sadness,* n (%) | 3 (18) | 7 (50) | 5 (62) | <.05 |
| Hypertension, n (%) | 8 (47) | 8 (57) | 4 (50) | >.20 |
| Hyperlipidemia, n (%) | 13 (76) | 9 (64) | 7 (88) | >.20 |
| Coronary heart disease, n (%) | 4 (24) | 1 (7) | 1 (12) | >.20 |
| Atrial fibrillation, n (%) | 3 (18) | 4 (29) | 1 (12) | >.20 |
| Diabetes mellitus, n (%) | 3 (18) | 3 (21) | 2 (25) | >.20 |
| Smoker, n (%) | 8 (47) | 4 (29) | 2 (25) | >.20 |
| Prior stroke on imaging, n (%) | 5 (29) | 3 (21) | 1 (12) | >.20 |
| Genetic polymorphisms, n (%) | ||||
| IL1RN rs4251961 (C/T or C/C genotype) | 7 (41) | 8 (57) | 7 (88) | .03 |
| TLR4 299Gly/399Ile variant allele carriers | 4 (24) | 0 | 0 | .04 |
Abbreviations: FAS, Fatigue Assessment Scale; IL1RN, interleukin-1 receptor antagonist gene; NIHSS, National Institutes of Health Stroke Scale; TLR4, toll-like receptor-4 gene.
*
Endorsed sadness at any time point during the study likelihood ratio.