Table 2.
Analysis of variance results within regions of interest demonstrating a main effect of group, a main effect of visit, and an interaction of group with visit for the valuation and cognition circuitry. Coordinates are presented in RAI format.
| Analysis of variance | Post hoc Comparisons |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Peak MNI Coordinates |
||||||||||||
| Region | L/R | BA | Volume (µL) |
Min cluster size (µL) |
x | y | z |
peak F |
Cohen’s d |
Contrast | z | p |
| VALUATION CIRCUITRY (BETA REGRESSOR) | ||||||||||||
| Group (RAN vs CW) | ||||||||||||
| Anterior Cingulate | L | 33/24 | 1080 | 240 | −12 | 30 | 18 | 13.3 | 1.2 | n.s. | ||
| R | 33/24 | 376 | 240 | 16 | 18 | 28 | 6.7 | 0.8 | n.s. | |||
| Posterior Cingulate | L | 23 | 296 | 226 | −8 | −26 | 32 | 9.0 | 1.0 | n.s. | ||
| R | 31 | 880 | 218 | 14 | −24 | 34 | 9.2 | 1.0 | n.s. | |||
| Visit (Hungry vs Satiated) | ||||||||||||
| None | ||||||||||||
| Group × Visit | ||||||||||||
| Ventral Striatum | L | 576 | 128 | −6 | 12 | −4 | 9.4 | 1.0 | Satiated: RAN > CW | 2.2 | 0.1 | |
| R | 1136 | 128 | 16 | 22 | −8 | 8.1 | 0.9 | CW: Hungry > Satiated | 2.7 | 0.04 | ||
| Satiated: RAN > CW | 2.8 | 0.03 | ||||||||||
| Dorsal Anterior Caudate | L | 3192 | 168 | −18 | 22 | 8 | 15.5 | 1.3 | CW: Hungry > Satiated | 2.4 | 0.08 | |
| Satiated: RAN > CW | 2.7 | 0.03 | ||||||||||
| R | 4096 | 168 | 16 | 14 | 6 | 16.2 | 1.3 | CW: Hungry > Satiated | 2.8 | 0.02 | ||
| Satiated: RAN > CW | 3.2 | 0.008 | ||||||||||
| Anterior Cingulate | L | 32/24 | 1832 | 240 | −6 | 36 | −4 | 9.7 | 1.0 | CW: Hungry > Satiated | 2.4 | 0.07 |
| Satiated: RAN > CW | 3.1 | 0.01 | ||||||||||
| 33/24 | 1800 | −8 | 18 | 22 | 11.0 | 1.1 | CW: Hungry > Satiated | 2.8 | 0.02 | |||
| Satiated: RAN > CW | 3.3 | 0.01 | ||||||||||
| 24 | 984 | −2 | 0 | 46 | 7.1 | 0.8 | CW: Hungry > Satiated | 2.8 | 0.03 | |||
| Satiated: RAN > CW | 3.0 | 0.01 | ||||||||||
| R | 33/24/32 | 6408 | 240 | 10 | 14 | 28 | 18.7 | 1.4 | CW: Hungry > Satiated | 3.4 | 0.003 | |
| Satiated: RAN > CW | 3.8 | <0.001 | ||||||||||
| Posterior Cingulate | L | 31 | 2112 | 226 | −6 | −32 | 34 | 7.6 | 0.9 | n.s. | ||
| R | 31/23/24 | 4296 | 218 | 4 | −38 | 30 | 8.8 | 1.0 | n.s. | |||
| COGNITIVE CIRCUITRY (DELTA REGRESSOR) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Group (RAN vs CW) | ||||||||||||
| Middle Frontal Gyrus | L | 8 | 1144 | 304 | −38 | 30 | 30 | 10.6 | 1.0 | RAN > CW | 2.8 | 0.005 |
| 6 | 528 | −48 | 8 | 40 | 7.1 | 1.0 | n .s. | |||||
| 6 | 376 | −38 | 20 | 54 | 13.1 | 1.2 | n.s. | |||||
| R | 6/8 | 2040 | 304 | 34 | 22 | 60 | 11.4 | 1.1 | RAN > CW | 2.9 | 0.004 | |
| 6 | 384 | 50 | 8 | 42 | 8.7 | 0.9 | n.s. | |||||
| Visit (Hungry vs Satiated) | ||||||||||||
| Middle Frontal Gyrus | L | 6/8 | 4920 | 304 | −32 | 12 | 42 | 15.3 | 1.3 | Satiated > Hungry | 2.9 | 0.004 |
| R | 8 | 312 | 304 | 38 | 24 | 34 | 7.4 | 0.9 | n.s. | |||
| Insula | L | 13 | 568 | 224 | −37 | 2 | 2 | 13.2 | 1.2 | Satiated > Hungry | 3.6 | <0.001 |
| 13 | 384 | −26 | 20 | −4 | 8.1 | 0.9 | Satiated > Hungry | 2.7 | 0.008 | |||
| 13 | 248 | −32 | −16 | 0 | 9.1 | 1.0 | Satiated > Hungry | 2.9 | 0.004 | |||
| Ventrolateral Prefrontal Cortex | L | 44/45 | 3000 | 240 | −54 | 18 | 14 | 14.0 | 1.2 | Satiated > Hungry | 2.8 | 0.005 |
| R | 45 | 240 | 224 | 56 | 26 | 20 | 7.6 | 0.9 | n.s. | |||
| Group × Visit | ||||||||||||
| Middle Frontal Gyrus | L | 6 | 600 | 304 | −30 | 8 | 62 | 11.1 | 1.1 | CW: Hungry > Satiated | 2.6 | 0.04 |
| Satiated: RAN > CW | 2.7 | 0.03 | ||||||||||
| Insula | L | 13 | 264 | 224 | −40 | −2 | 8 | 9.5 | 1.0 | CW: Satiated > Hungry | 3.6 | 0.002 |
| R | 13 | 456 | 224 | 40 | 10 | −4 | 8.5 | 0.9 | CW: Satiated > Hungry | 3.1 | 0.009 | |
| 13 | 320 | 34 | 8 | 8 | 10.0 | 1.0 | n.s. | |||||
| Ventrolateral Prefrontal Cortex | R | 45/47 | 264 | 224 | 38 | 26 | −6 | 8.7 | 0.9 | CW: Satiated > Hungry | 2.9 | 0.02 |
| Superior Parietal Cortex | L | 544 | 256 | −22 | −50 | 38 | 13.0 | 1.2 | n.s. | |||
| R | 408 | 248 | 22 | −54 | 48 | 9.0 | 1.0 | n.s. | ||||
Note: BA: Brodmann area; CW: healthy comparison women; L: left; n.s.: not significant; R: right; RAN: women recovered from anorexia nervosa.
Small volume correction was determined with Monte-Carlo simulations (via AFNI’s 3dClustSim) to guard against false positives. Post hoc analyses were conducted using glht from the multcomp package in R to calculate general linear hypotheses using Tukey’s all-pair comparisons.