Table 4.

Brain Region	[3H]U69,593 KOR Relative Binding
	Titi Monkey	Human9,10	Rat11,12	Guinea Pig11	Prairie Vole8
Cingulate Gyrus	+
Striatum
Caudate	+	++	+	+++	+++
Putamen	+	++	+	+++	+++
Nucleus Accumbens Shell	+	++	++	+++	++++
Nucleus Accumbens Core	+	++	++	+++	+++
NUDAP	0		N/A	N/A	N/A
Claustrum	++++	++++	++	++++	+++
Globus Pallidus Internal	+	+	+	+
Ventral Pallidum	++				++
Amygdala/Extended Amygdala		+++	+	+
Anterior Amygdala	+
Basolateral Amygdala	+
Basomedial Amygdala	+
Cortical Amygdala	+
Medial Amygdala	+
Central Amygdala	+
Paralaminar n.	0
Lateral Amygdala	+
Bed Nucleus of the Stria
Terminalis	0		+	+
Septal Region
Medial Septum	+		+	+
Lateral Septum	+		+	+
Diagonal Band	+
Hippocampus			0
Septohippocampal n.	0
Presubiculum	+
Entorhinal cortex	+
CA1	+	+++
CA3	+	+
Hypothalamus	+	+++*10	+	+	0
Anterior hypothalamic n.
Arcuate N.
Dorsomedial hypothalamic n.
Lateral hypothalamic n.			+	+
Medial preoptic area
Paraventricular hypothalamic n.
Suprachiasmatic hypothalamic n.
Supraoptic hypothalamic. N.
Ventromedial hypothalamic n.			+
Septohypothalamic n.
Mammillary body	0		+	+
Substantia Nigra	0		+	+	+++
Thalamus	0	+++*10
Anteroventral thalamic n.
Ventrolateral thalamic n.
ventral anterior thalamic n.
Mediodorsal thalamic n.			+	+
Pulvinar
Interpeduncular n.	0		+

⁹deLanerolle et al., 1997

¹⁰Quirion et al., 1987

¹¹Unterwald et al., 1991

¹²Zukin et al., 1988

++++, very dense; +++ dense, ++ moderate, + light, 0 not detectable, N/A not applicable, blank cells = no data, *¹⁰Quirion et al., 1987 does not specify nuclei or supply images