Table 1. KEGG pathways and gene ontology analysis for Down Syndrome associated DMRs. The table reports the significantly enriched KEGG pathways and gene ontologies, as resulting from the analysis with Fisher's exact test and GOrilla platform (see Materials and methods section).

Description	q-value
Kegg Pathway
Ribosome	0.013
Allograft rejection	0.013
Graft-versus-host disease	0.013
Cell adhesion molecules (CAMs)	0.013
Autoimmune thyroid disease	0.013
PI3K-Akt signaling pathway	0.013
Basal cell carcinoma	0.013
HTLV-I infection	0.034
Type I diabetes mellitus	0.040
Gene Ontology Process
System process (GO:0003008 )	0.027
Anatomical structure morphogenesis (GO:0009653 )	0.032
Regulation of signal transduction (GO:0009966 )	0.027
Multicellular organismal process (GO:0032501 )	0.000
Single-organism process (GO:0044699 )	0.015
Single-multicellular organism process (GO:0044707 )	0.000
Positive regulation of biological process (GO:0048518 )	0.027
Embryonic organ morphogenesis (GO:0048562 )	0.006
Regulation of response to stimulus (GO:0048583 )	0.035
Embryonic skeletal system morphogenesis (GO:0048704 )	0.018
Anatomical structure development (GO:0048856 )	0.017
Regulation of body fluid levels (GO:0050878 )	0.038