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Localization of the AZT resistance substitutions. The putative locations of the four substituted amino acid residues in the highly resistant mt4 (I211, T224, T345, K350) are highlighted in red in a structural model of the SFVmac RT polymerase domain. The polymerase active site motif YVDD is highlighted in blue. The model is based on the structure of XMRV RT (PDB: 4HKQ) with an RNA/DNA hybrid substrate and was generated using the Program SWISS-MODEL [25].
