Table 2.
Sprague Dawley mean blood clinical chemistry value in chronic oral toxicity test.
| Group | GLU (mg/dL) |
BUN (mg/dL) |
CREA (mg/dL) |
CHOL (mg/dL) |
TG (mg/dL) |
URIC (mg/dL) |
TP (g/dL) |
ALB (g/dL) |
GLOB (g/dL) |
Bili-T (U/L) |
AST (U/L) |
ALT (U/L) |
ALP (U/L) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Male | |||||||||||||
| Control | |||||||||||||
| Mean | 137.56 | 23.21 | 0.66 | 230.29 | 192.29 | 1.64 | 9.43 | 4.80 | 4.63 | 0.19 | 99.29 | 68.76 | 80.29 |
| SD | 15.30 | 2.17 | 0.09 | 48.24 | 64.14 | 0.52 | 1.24 | 0.56 | 0.78 | 0.02 | 18.07 | 16.94 | 18.56 |
| 10 mg/kg | |||||||||||||
| Mean | 155.22 | 23.73 | 0.66 | 256.08 | 210.08 | 1.82 | 9.26 | 4.62 | 4.64 | 0.17 | 95.73 | 68.29 | 77.38 |
| SD | 35.92 | 3.12 | 0.11 | 60.33 | 68.66 | 0.68 | 0.89 | 0.37 | 0.65 | 0.03 | 14.04 | 14.99 | 16.43 |
| 100 mg/kg | |||||||||||||
| Mean | 162.46 | 24.98 | 0.70 | 264.50 | 194.92 | 2.18 | 9.89 | 5.01 | 4.88 | 2.17 | 100.20 | 69.98 | 81.50 |
| SD | 29.86 | 4.34 | 0.14 | 53.29 | 51.49 | 0.53 | 0.88 | 0.65 | 0.52 | 6.87 | 21.01 | 20.43 | 14.06 |
| 1,000 mg/kg | |||||||||||||
| Mean | 182.29 | 24.81 | 0.60 | 279.82 | 211.91 | 2.73 | 9.23 | 4.61 | 4.62 | 0.15 | 80.11 | 58.26 | 80.18 |
| SD | 38.54 | 2.87 | 0.14 | 84.66 | 97.57 | 0.85 | 1.05 | 0.45 | 0.84 | 0.04 | 22.03 | 11.19 | 9.10 |
|
| |||||||||||||
| Female | |||||||||||||
| Control | |||||||||||||
| Mean | 185.88 | 23.06 | 0.70 | 173.50 | 115.71 | 2.38 | 10.34 | 5.94 | 4.41 | 0.27 | 141.31 | 73.76 | 41.29 |
| SD | 41.89 | 2.89 | 0.08 | 31.71 | 20.01 | 0.81 | 0.83 | 0.44 | 0.48 | 0.06 | 19.97 | 14.02 | 7.28 |
| 10 mg/kg | |||||||||||||
| Mean | 168.03 | 22.10 | 0.64 | 173.79 | 131.57 | 2.34 | 9.74 | 5.67 | 4.06 | 0.23 | 137.86 | 69.34 | 40.36 |
| SD | 35.19 | 2.41 | 0.10 | 35.43 | 26.26 | 0.79 | 1.11 | 0.55 | 0.66 | 0.06 | 29.51 | 18.77 | 11.04 |
| 100 mg/kg | |||||||||||||
| Mean | 157.04 | 22.67 | 0.66 | 180.00 | 119.09 | 1.89 | 10.59 | 5.98 | 4.62 | 0.27 | 149.45 | 77.83 | 47.45 |
| SD | 23.06 | 3.57 | 0.09 | 48.49 | 30.03 | 0.46 | 1.09 | 0.60 | 0.59 | 0.09 | 28.34 | 15.41 | 13.38 |
| 1,000 mg/kg | |||||||||||||
| Mean | 158.46 | 24.34 | 0.63 | 176.00 | 120.00 | 1.96 | 10.04 | 5.76 | 4.30 | 0.21 | 126.00 | 57.00 | 42.78 |
| SD | 27.49 | 4.15 | 0.13 | 36.24 | 36.48 | 0.68 | 1.13 | 0.49 | 0.77 | 0.04 | 39.37 | 21.07 | 23.87 |
GLU: glucose, BUN: blood urea nitrogen, CREA: creatinine, CHOL: cholesterol, TG: triglyceride, TP: total protein, ALB: albumin, GLOB: globulin, Bili-T: total bilirubin, AST: aspartate aminotransferase, ALT: alanine transaminase, and ALP: alkaline phosphatase.