Table 2.
Combination drug effects of FWGE with cisplatin or docetaxel in SKOV-3 and ES-2 cells. The combination drug index (CDI) was based on cell viability data obtained after 48 h of treatment with FWGE combined with cisplatin or docetaxel and was calculated using the CalcuSyn software. CDI < 1 indicates a synergistic effect; CDI = 1 indicates an additive effect; and CDI > 1 indicates an antagonistic effect.
| SKOV-3 | ES-2 | ||
|---|---|---|---|
| CDI | CDI | ||
| Cisplatin (μM) | Cisplatin (μM) | ||
| 1 | 23.73 | 1 | 5.227 |
| 2.5 | 6.601 | 2.5 | 3.658 |
| 5 | 0.764 | 5 | 0.305 |
| 10 | 0.369 | 10 | 1.032 |
| Docetaxel (nM) | Docetaxel (nM) | ||
| 1 | 4.114 | 1 | 6.859 |
| 2.5 | 1.792 | 5 | 5.568 |
| 5 | 0.993 | 10 | 1.928 |
| 10 | 0.996 | 100 | 0.639 |