Table 2.
Differences in genotype and allele frequencies of JAK3 polymorphisms between RA patients with or without cardiovascular (CV) events.
| SNP | 1/2 | Subgroup | Genotype, N (%) | Allele test | ||||
|---|---|---|---|---|---|---|---|---|
| 1/1 | 1/2 | 2/2 | MAF | P * | OR [95% CI]* | |||
| rs3212780 | G/A | Without CV events | 909 (52.51) | 688 (39.75) | 134 (7.74) | 0.28 | ||
| With CV events | 191 (50.26) | 160 (42.11) | 29 (7.63) | 0.29 | 0.51 | 0.93 [0.75–1.06] | ||
|
| ||||||||
| rs3212752 | T/C | Without CV events | 1547 (88.30) | 203 (11.59) | 2 (0.11) | 0.06 | ||
| With CV events | 349 (90.88) | 34 (8.85) | 1 (0.26) | 0.05 | 0.35 | 0.81 [0.52–1.26] | ||
RA: rheumatoid arthritis. CV: cardiovascular. SNP: single nucleotide polymorphisms. MAF: minor allele frequency. OR: odds ratio. CI: confidence interval.
*Adjusted for sex, age at the time of ultrasonography study, follow-up time, and traditional CV risk factors (hypertension, diabetes mellitus, dyslipidemia, obesity, and smoking habit) by logistic regression.