Table 1. Inhibitor sensitivity of yeast Sec61p mutants selected by their resistance to compound 1.

The Sec61p mutants isolated as resistant to compound 1 were tested for the prl phenotype and CPY translocation defects as in Junne et al. (Junne et al., 2007). S, sensitive; R, resistant (IC₅₀ at least 50-fold higher than wild-type); (R), moderately resistant (IC₅₀ at least two-fold higher than wild-type).

^aThe color code of mutations conferring resistance to at least one compound corresponds to that used in Fig. 3A, lower panel;

^bcorresponding IC₅₀ curves are shown in supplementary material Fig. S3;

^cr² values are shown where a sigmoidal curve could be fitted.