Table 2. Inhibitor sensitivity of previously described Sec61 mutants.

These Sec61 mutants have previously been characterized by Junne et al. (Junne et al., 2006; Junne et al., 2007; Junne et al., 2010). prl phenotype and CPY translocation defects were analyzed by Junne et al. (Junne et al., 2007). S, sensitive; HS, hypersensitive (IC₅₀ at least two-fold lower than wild-type); R, resistant; (R), moderately resistant (IC₅₀ at least two-fold higher than wild-type); n.d., not determined.

^aThe color code of mutations conferring resistance to at least one compound corresponds to that used in Fig. 3A, lower panel;

^bcorresponding IC₅₀ curves are shown in supplementary material Fig. S3;

^cr² values are shown where a sigmoidal curve could be fitted.