Table 1.
The effects of acute and chronic treatment with different doses of NAC on neuromuscular coordination
| Treatment group | Dose (mg/kg) |
Acute
stay time on rotarod (s) |
Chronic
stay time on rotarod (s) |
||
|---|---|---|---|---|---|
| Baseline | Test | Baseline | Test | ||
| Vehicle (EDTA) | - | 250.6±21.9 | 259.4±18.1 | 244.6±20.1 | 255.4±16.6 |
| NAC | 25 | - | - | 230.1±26.5 | 229.5±23.1 |
| 50 | 222.7±24.8 | 251.4±26.4 | 237.0±25.9 | 226.4±25.1 | |
| 75 | 244.7±24.4 | 254.4±26.1 | 231.6±25.2 | 180.5±20.9 | |
| 100 | - | - | 250.3±20.1 | 166.5±21.2* | |
| 150 | 246.0±21.1 | 249.3±23.1 | 233.7±23.0 | 61.6±15.6* | |
| 300 | 233.0±26.0 | 250.8±21.15 | - | - | |
| Diazepam | 1 | 225.1±22.4 | 103.7±18.1* | - | - |
| Ethosuximide | 150 | - | - | 244.3±23.1 | 236.7±20.2 |
Data were presented as mean±SEM of stay time on rotarod (n=7/group) before (baseline) and after (test) the injection of different doses of NAC, vehicle, diazepam or ethosuximide. *Indicates significance (P<0.01) in comparison with vehicle