Table 3.
Effects of neurotransmitters antagonists on the antinociceptive action of Curcumin (40 mg/kg)
| Treatment |
Dose
(mg/kg IP) |
Latency
Time (sec) |
Writhing test Inhibition P value
(Mean±SEM) |
Inhibition % P value% | P value |
|---|---|---|---|---|---|
| Curcumin | 40 | 614±19 | 42±0.3 | 33 | 0.0002 vs.vehicle |
| Naloxone+Curcumin | 2+40 | 30±1.6 | 55±1.8 | 12 | 0.0009 vs. curcumin |
| cyproheptadine+Curcumin | 4+40 | 216±13 | 53±1 | 19 | 0.0045 vs. curcumin |
| Phentolamine+Curcumin | 20+40 | 603±11 | 43±0.4 | 31 | 0.0003 vs. vehicle |
| Chlorpheniramine+Curcumin | 10+40 | 605±14 | 44±0.6 | 30 | 0.0005 vs. vehicle |
| Cimetidine+Curcumin | 10+40 | 600±17 | 40±1 | 36 | 0.0001 vs. vehicle |
| Metoclopramide+Curcumin | 2+40 | 601±12 | 46±0.5 | 26 | 0.0013 vs. vehicle |
| Vehicle (DMSO 5%) | 10 (ml/kg) | 324±34 | 63±4.2 | ------ | ----- |
N=8 for each group